Research progress of lncRNA on regulation of energy metabolism in tumor cells_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

MA Yingbo , ZHANG Xiaodong , YANG Zhaoguo , YANG Liang ,  LI Hangyu

Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, P.R.China;

Corresponding author：

LI Hangyu, Email: li_hangyu@126.com

Keywords：

long non-coding RNA; tumor; energy metabolism; Warburg effect

DOI：

10.7507/1007-9424.201606052

Video：

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Objective To summarize the latest research progress of tumor energy metabolism regulated by long non-coding RNA (lncRNA). Method Literatures about the recent studies on the bioenergetic metabolic mechanisms regulated by lncRNA in tumor cells were reviewed according to the results searched from PubMed database, Springer database, HighWire database, and so on. Results Aerobic glycolysis (Warburg effect) was regarded as the most important characteristics of energy metabolism in tumor cells. lncRNA could regulate many key progressions involved energy metabolism in tumor cells, such as glucose metabolism, lipid metabolism, and glutamine metabolism, resulting in accelerated uptake of glucose, decomposition of glutamine, and formation of lipid. Conclusions The functions and mechanisms of energy metabolism in tumor cells regulated by lncRNA are entirely unclear. The role of lncRNA played in cancer needs to be understood, which may contribute to new tumor biomarker detection and effective treatment strategies.

Citation： MA Yingbo, ZHANG Xiaodong, YANG Zhaoguo, YANG Liang, LI Hangyu. Research progress of lncRNA on regulation of energy metabolism in tumor cells. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(3): 381-385. doi: 10.7507/1007-9424.201606052 Copy

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2.	Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs. Cell, 2009, 136(4): 629-641.
3.	Fang Y, Fullwood MJ. Roles, functions, and mechanisms of long non-coding RNAs in cancer. Genomics Proteomics Bioinformatics, 2016, 14(1): 42-54.
4.	Khaitovich P, Kelso J, Franz H, et al. Functionality of intergenic transcription: an evolutionary comparison. PLoS Genets, 2006, 2(10): e171.
5.	Wang KC, Chang HY. Molecular mechanisms of long noncoding RNAs. Mol Cell, 2011, 43(6): 904-914.
6.	Rinn JL, Chang HY. Genome regulation by long noncoding RNAs. Annu Rev Biochem, 2012, 81: 145-166.
7.	Zhao XY, Lin JD. Long noncoding RNAs: a new regulatory code in metabolic control. Trends Biochem Sci, 2015, 40(10): 586-596.
8.	Warburg O. On the origin of cancer cells. Science, 1956, 123(3191): 309-314.
9.	Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science, 2009, 324(5930): 1029-1033.
10.	Prensner JR, Chinnaiyan AM. The emergence of lncRNAs in cancer biology. Cancer Discov, 2011, 1(5): 391-407.
11.	Huarte M, Guttman M, Feldser D, et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell, 2010, 142(3): 409-419.
12.	Yang F, Zhang H, Mei Y, et al. Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect. Mol Cell, 2014, 53(1): 88-100.
13.	Zhang XQ, Kiang KM, Wang YC, et al. IDH1 mutation-associated long non-coding RNA expression profile changes in glioma. J Neurooncol, 2015, 125(2): 253-263.
14.	Srikantan V, Zou Z, Petrovics G, et al. PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. Proc Natl Acad Sci U S A, 2000, 97(22): 12216-12221.
15.	Yang L, Lin C, Jin C, et al. lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. Nature, 2013, 500(7464): 598-602.
16.	Hung CL, Wang LY, Yu YL, et al. A long noncoding RNA connects c-Myc to tumor metabolism. Proc Natl Acad Sci U S A, 2014, 111(52): 18697-18702.
17.	Wang Y, Chen W, Yang C, et al. Long non-coding RNA UCA1a(CUDR) promotes proliferation and tumorigenesis of bladder cancer. Int J Oncol, 2012, 41(1): 276-284.
18.	Wang XS, Zhang Z, Wang HC, et al. Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. Clin Cancer Res, 2006, 12(16): 4851-4858.
19.	Yang C, Li X, Wang Y, et al. Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells. Gene, 2012, 496(1): 8-16.
20.	Li Z, Li X, Wu S, et al. Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway. Cancer Sci, 2014, 105(8): 951-955.
21.	Graham LD, Pedersen SK, Brown GS, et al. Colorectal neoplasia differentially expressed (CRNDE), a novel gene with elevated expression in colorectal adenomas and adenocarcinomas. Genes Cancer, 2011, 2(8): 829-840.
22.	Zhang X, Sun S, Pu JK, et al. Long non-coding RNA expression profiles predict clinical phenotypes in glioma. Neurobiol Dis, 2012, 48(1): 1-8.
23.	Khalil AM, Guttman M, Huarte M, et al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A, 2009, 106(28): 11667-11672.
24.	Ellis BC, Graham LD, Molloy PL. CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism. Biochim Biophys Acta, 2014, 1843(2): 372-386.
25.	Rupaimoole R, Lee J, Haemmerle M, et al. Long noncoding RNA ceruloplasmin promotes cancer growth by altering glycolysis. Cell Rep, 2015, 13(11): 2395-2402.
26.	Hensley CT, Wasti AT, DeBerardinis RJ. Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Invest, 2013, 123(9): 3678-3684.
27.	Shanware NP, Mullen AR, DeBerardinis RJ, et al. Glutamine: pleiotropic roles in tumor growth and stress resistance. J Mol Med (Berl), 2011, 89(3): 229-236.
28.	Zhang J, Wang C, Chen M, et al. Epigenetic silencing of glutaminase 2 in human liver and colon cancers. BMC Cancer, 2013, 13: 601.
29.	Li HJ, Li X, Pang H, et al. Long non-coding RNA UCA1 promotes glutamine metabolism by targeting miR-16 in human bladder cancer. Jpn J Clin Oncol, 2015, 45(11): 1055-1063.
30.	Menendez JA, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer, 2007, 7(10): 763-777.
31.	Panzitt K, Tschernatsch MM, Guelly C, et al. Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. Gastroenterology, 2007, 132(1): 330-342.
32.	Wang J, Liu X, Wu H, et al. CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res, 2010, 38(16): 5366-5383.
33.	Cui M, Xiao Z, Wang Y, et al. Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway. Cancer Res, 2015, 75(5): 846-857.
34.	Parrales A, Iwakuma T. p53 as a regulator of lipid metabolism in cancer. Int J Mol Sci, 2016, 17(12): 2074.
35.	Chen Z. Progress and prospects of long noncoding RNAs in lipid homeostasis. Mol Metab, 2016, 5(3): 164-170.
36.	Kornfeld JW, Brüning JC. Regulation of metabolism by long, non-coding RNAs. Front Genet, 2014, 5: 57.

1. Maruyama R, Suzuki H. Long noncoding RNA involvement in cancer. BMB Rep, 2012, 45(11): 604-611.
2. Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs. Cell, 2009, 136(4): 629-641.
3. Fang Y, Fullwood MJ. Roles, functions, and mechanisms of long non-coding RNAs in cancer. Genomics Proteomics Bioinformatics, 2016, 14(1): 42-54.
4. Khaitovich P, Kelso J, Franz H, et al. Functionality of intergenic transcription: an evolutionary comparison. PLoS Genets, 2006, 2(10): e171.
5. Wang KC, Chang HY. Molecular mechanisms of long noncoding RNAs. Mol Cell, 2011, 43(6): 904-914.
6. Rinn JL, Chang HY. Genome regulation by long noncoding RNAs. Annu Rev Biochem, 2012, 81: 145-166.
7. Zhao XY, Lin JD. Long noncoding RNAs: a new regulatory code in metabolic control. Trends Biochem Sci, 2015, 40(10): 586-596.
8. Warburg O. On the origin of cancer cells. Science, 1956, 123(3191): 309-314.
9. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science, 2009, 324(5930): 1029-1033.
10. Prensner JR, Chinnaiyan AM. The emergence of lncRNAs in cancer biology. Cancer Discov, 2011, 1(5): 391-407.
11. Huarte M, Guttman M, Feldser D, et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell, 2010, 142(3): 409-419.
12. Yang F, Zhang H, Mei Y, et al. Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect. Mol Cell, 2014, 53(1): 88-100.
13. Zhang XQ, Kiang KM, Wang YC, et al. IDH1 mutation-associated long non-coding RNA expression profile changes in glioma. J Neurooncol, 2015, 125(2): 253-263.
14. Srikantan V, Zou Z, Petrovics G, et al. PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. Proc Natl Acad Sci U S A, 2000, 97(22): 12216-12221.
15. Yang L, Lin C, Jin C, et al. lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. Nature, 2013, 500(7464): 598-602.
16. Hung CL, Wang LY, Yu YL, et al. A long noncoding RNA connects c-Myc to tumor metabolism. Proc Natl Acad Sci U S A, 2014, 111(52): 18697-18702.
17. Wang Y, Chen W, Yang C, et al. Long non-coding RNA UCA1a(CUDR) promotes proliferation and tumorigenesis of bladder cancer. Int J Oncol, 2012, 41(1): 276-284.
18. Wang XS, Zhang Z, Wang HC, et al. Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. Clin Cancer Res, 2006, 12(16): 4851-4858.
19. Yang C, Li X, Wang Y, et al. Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells. Gene, 2012, 496(1): 8-16.
20. Li Z, Li X, Wu S, et al. Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway. Cancer Sci, 2014, 105(8): 951-955.
21. Graham LD, Pedersen SK, Brown GS, et al. Colorectal neoplasia differentially expressed (CRNDE), a novel gene with elevated expression in colorectal adenomas and adenocarcinomas. Genes Cancer, 2011, 2(8): 829-840.
22. Zhang X, Sun S, Pu JK, et al. Long non-coding RNA expression profiles predict clinical phenotypes in glioma. Neurobiol Dis, 2012, 48(1): 1-8.
23. Khalil AM, Guttman M, Huarte M, et al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A, 2009, 106(28): 11667-11672.
24. Ellis BC, Graham LD, Molloy PL. CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism. Biochim Biophys Acta, 2014, 1843(2): 372-386.
25. Rupaimoole R, Lee J, Haemmerle M, et al. Long noncoding RNA ceruloplasmin promotes cancer growth by altering glycolysis. Cell Rep, 2015, 13(11): 2395-2402.
26. Hensley CT, Wasti AT, DeBerardinis RJ. Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Invest, 2013, 123(9): 3678-3684.
27. Shanware NP, Mullen AR, DeBerardinis RJ, et al. Glutamine: pleiotropic roles in tumor growth and stress resistance. J Mol Med (Berl), 2011, 89(3): 229-236.
28. Zhang J, Wang C, Chen M, et al. Epigenetic silencing of glutaminase 2 in human liver and colon cancers. BMC Cancer, 2013, 13: 601.
29. Li HJ, Li X, Pang H, et al. Long non-coding RNA UCA1 promotes glutamine metabolism by targeting miR-16 in human bladder cancer. Jpn J Clin Oncol, 2015, 45(11): 1055-1063.
30. Menendez JA, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer, 2007, 7(10): 763-777.
31. Panzitt K, Tschernatsch MM, Guelly C, et al. Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. Gastroenterology, 2007, 132(1): 330-342.
32. Wang J, Liu X, Wu H, et al. CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res, 2010, 38(16): 5366-5383.
33. Cui M, Xiao Z, Wang Y, et al. Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway. Cancer Res, 2015, 75(5): 846-857.
34. Parrales A, Iwakuma T. p53 as a regulator of lipid metabolism in cancer. Int J Mol Sci, 2016, 17(12): 2074.
35. Chen Z. Progress and prospects of long noncoding RNAs in lipid homeostasis. Mol Metab, 2016, 5(3): 164-170.
36. Kornfeld JW, Brüning JC. Regulation of metabolism by long, non-coding RNAs. Front Genet, 2014, 5: 57.

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