Treatment options and prognosis of malignant tumors with hepatic metastasis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

XUN Jingyu , SUN Chen , LI Fujun ,  WU Dequan

The Sixth Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, P.R. China;

Corresponding author：

WU Dequan, Email: dqwu56@163.com

Keywords：

hepatic metastasis; malignant tumor; treatment; prognosis

DOI：

10.7507/1007-9424.201607058

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the treatment and prognosis of malignant tumors with hepatic metastasis. Methods Review and analysis of recent relevant literatures at home and abroad of malignant tumors with liver metastasis, according to the different treatments were summarized. Evaluation of the patients’ clinically curative effect and survival situation was performed under different treatments. Results With the development of imaging and surgical techniques, and deeply understanding of malignant tumor, many malignant tumors with liver metastasis could be found and treated, and previous concept of treatment for malignant tumors with liver metastasis was also fundamentally changed, and radical resection of the primary lesions and liver metastasis was the best way to get clinically curative effect for the patients with malignant tumors with liver metastasis. The treatments of malignant tumors with liver metastasis also included radio frequency ablation (RFA), transarterial chemoembolization (TACE), chemotherapy,¹²⁵I seed implantation, cryotherapy, stereotactic body radiation therapy (SBRT), laser-induced interstitial thermotherapy (LITT), gene targeting therapy, and so on. Conclusion Now for malignant tumors with liver metastasis, positive surgery and (or) individualized comprehensive treatment are taken more often, and they play positive role to prolong the survival and improve the prognosis of malignant tumors patients with liver metastasis.

Citation： XUN Jingyu, SUN Chen, LI Fujun, WU Dequan. Treatment options and prognosis of malignant tumors with hepatic metastasis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(3): 386-390. doi: 10.7507/1007-9424.201607058 Copy

1.	Dueland S, Hagness M, Line PD,et al. Is liver transplantation an option in colorectal cancer patients with nonresectable liver metastases and progression on all lines of standard chemotherapy? Ann Surg Oncol, 2015, 22(7): 2195-2200.
2.	Hoffmann K, Bulut S, Tekbas A,et al. Is hepatic resection for non-colorectal, non-neuroendocrine liver metastases justified? Ann Surg Oncol, 2015, 22 Suppl 3: S1083-S1092.
3.	Shen Y, Huang S, Hu X,et al. Clinical effect of laparoscopic hepatectomy in treating liver metastasis of colon cancer: a systematic review and meta analysis. J Clin Hepatol, 2014, 30(12): 1287-1291.
4.	Ferro A, Peleteiro B, Malvezzi M,et al. Worldwide trends in gastric cancer mortality (1980-2011), with predictions to 2015, and incidence by subtype. Eur J Cancer, 2014, 50(7): 1330-1344.
5.	Markar SR, Mackenzie H, Mikhail S,et al. Surgical resection of hepatic metastases from gastric cancer: outcomes from national series in England. Gastric Cancer, 2016,[Epub ahead of print].
6.	Oki E, Tokunaga S, Emi Y,et al. Surgical treatment of liver metastasis of gastric cancer: a retrospective multicenter cohort study (KSCC1302). Gastric Cancer, 2016, 19(3): 968-976.
7.	Elferink MA, de Jong KP, Klaase JM,et al. Metachronous metastases from colorectal cancer: a population-based study in North-East Netherlands. Int J Colorectal Dis, 2015, 30(2): 205-212.
8.	Cucchetti A, Ferrero A, Cescon M,et al. Cure model survival analysis after hepatic resection for colorectal liver metastases. Ann Surg Oncol, 2015, 22(6): 1908-1914.
9.	Norén A, Eriksson HG, Olsson LI. Selection for surgery and survival of synchronous colorectal liver metastases; a nationwide study. Eur J Cancer, 2016, 53: 105-114.
10.	Ratti F, Schadde E, Masetti M,et al. Strategies to increase the resectability of patients with colorectal liver metastases: a multi-center case-match analysis of ALPPS and conventional two-stage hepatectomy. Ann Surg Oncol, 2015, 22(6): 1933-1942.
11.	Björnsson B, Sparrelid E, Røsok B,et al. Associating liver partition and portal vein ligation for staged hepatectomy in patients with colorectal liver metastases-intermediate oncological results. Eur J Surg Oncol, 2016, 42(4): 531-537.
12.	Charalampoudis P, Mantas D, Sotiropoulos GC,et al. Surgery for liver metastases from breast cancer. Future Oncol, 2015, 11(10): 1519-1530.
13.	Ruiz A, Castro-Benitez C, Sebagh M,et al. Repeat hepatectomy for breast cancer liver metastases. Ann Surg Oncol, 2015, 22 Suppl 3: S1057- S1066.
14.	Mehta RS, Liman AD, Passero VA,et al. Lung cancer with gastrointestinal metastasis - review of theories of metastasis with three rare case descriptions. Cancer Microenviron, 2013, 6(3): 203-211.
15.	张吉超, 邹磊, 李道堂, 等. 肺癌肝转移治疗的研究进展. 中国现代普通外科进展, 2014, 17(3): 246-248.
16.	张毅, 魏翔, 潘铁成. 非小细胞肺癌肝转移的同期外科治疗1例并文献复习. 中国肺癌杂志, 2009, 12(2): 179-182.
17.	Guner A, Son T, Cho I,et al. Liver-directed treatments for liver metastasis from gastric adenocarcinoma: comparison between liver resection and radiofrequency ablation. Gastric Cancer, 2016, 19(3): 951-960.
18.	Hwang JE, Kim SH, Jin J,et al. Combination of percutaneous radiofrequency ablation and systemic chemotherapy are effective treatment modalities for metachronous liver metastases from gastric cancer. Clin Exp Metastasis, 2014, 31(1): 25-32.
19.	Lee CW, Kim JH, Won HJ,et al. Percutaneous radiofrequency ablation of hepatic metastases from gastric adenocarcinoma after gastrectomy. J Vasc Interv Radiol, 2015, 26(8): 1172-1179.
20.	Vogl TJ, Farshid P, Naguib NN,et al. Thermal ablation therapies in patients with breast cancer liver metastases: a review. Eur Radiol, 2013, 23(3): 797-804.
21.	Taşçi Y, Aksoy E, Taşkın HE,et al. A comparison of laparoscopic radiofrequency ablationversus systemic therapy alone in the treatment of breast cancer metastasis to the liver. HPB (Oxford), 2013, 15(10): 789-793.
22.	Kümler I, Parner VK, Tuxen MK,et al. Clinical outcome of percutaneous RF-ablation of non-operable patients with liver metastasis from breast cancer. Radiol Med, 2015, 120(6): 536-541.
23.	Vogl TJ, Gruber-Rouh T, Eichler K,et al. Repetitive transarterial chemoembolization (TACE) of liver metastases from gastric cancer: local control and survival results. Eur J Radiol, 2013, 82(2): 258-263.
24.	冯涛聚, 王炜, 李付涛. 68例胃癌肝转移瘤进展期患者介入治疗的回顾性分析. 中国实用医药, 2016, 11(10): 78-79.
25.	Gruber-Rouh T, Marko C, Thalhammer A,et al. Current strategies in interventional oncology of colorectal liver metastases. Br J Radiol, 2016, 89(50): 60-69.
26.	Huppert P, Wenzel T, Wietholtz H. Transcatheter arterial chemoembolization (TACE) of colorectal cancer liver metastases by irinotecan-eluting microspheres in a salvage patient population. Cardiovasc Intervent Radiol, 2014, 37(1): 154-164.
27.	Fiorentini G, Aliberti C, Mulazzani L,et al. Chemoembolization in colorectal liver metastases: the rebirth. Anticancer Res, 2014, 34(2): 575-584.
28.	Qiu JL, Deng MG, Li W,et al. Hepatic resection for synchronous hepatic metastasis from gastric cancer. Eur J Surg Oncol, 2013, 39(7): 694-700.
29.	Ogata Y, Matono K, Tsuda H,et al. Randomized phase Ⅱ study of 5-fluorouracil hepatic arterial infusion with or without antineoplastons as an adjuvant therapy after hepatectomy for liver metastases from colorectal cancer. PLoS One, 2015, 10(3): e0120064.
30.	D’Angelica MI, Correa-Gallego C, Paty PB,et al. Phase Ⅱ trial of hepatic artery infusional and systemic chemotherapy for patients with unresectable hepatic metastases from colorectal cancer: conversion to resection and long-term outcomes. Ann Surg, 2015, 261(2): 353-360.
31.	Kodera Y, Fujitani K, Fukushima N,et al. Surgical resection of hepatic metastasis from gastric cancer: a review and new recommendation in the Japanese gastric cancer treatment guidelines. Gastric Cancer, 2014, 17(2): 206-212.
32.	Cavanna L, Bodini FC, Stroppa EM,et al. Advanced gastric cancer with liver and lymph node metastases successfully resected after induction chemotherapy with docetaxel, cisplatin and 5-fluorouracil. Chemotherapy, 2014, 60(4): 224-227.
33.	Yoshikawa T, Aoki K, Mitsuhashi Y,et al. A case of double cancer of initially unresectable sigmoid colon cancer and advanced gastric cancer treated with curative resection after mFOLFOX6 therapy. Gan To Kagaku Ryoho, 2016, 43(3): 365-368.
34.	Somashekhar SP, Ashwin KR, Zaveri SS,et al. Assessment of tumor response and resection rates in unresectable colorectal liver metastases following neoadjuvant chemotherapy with cetuximab. Indian J Surg Oncol, 2016, 7(1): 11-17.
35.	Li J, Xie Q, Wang W,et al. CT-guided implantation of (125)I seeds (permanent brachytherapy) for metastatic tumors of the hepatic portal system: effectiveness and safety in 13 patients. Brachytherapy, 2016, 15(2): 224-230.
36.	何津, 李强.¹²⁵I粒子植入治疗延迟性结肠癌肝转移的临床疗效. 中华肿瘤杂志, 2016, 38(3): 223-227.
37.	任庆, 熊锐华, 田秀荣, 等.¹²⁵I粒子植入联合化疗治疗结直肠癌术后肝转移的临床研究. 肿瘤防治研究, 2014, 41(6): 653-656.
38.	Bala MM, Riemsma RP, Wolff R,et al. Cryotherapy for liver metastases. Cochrane Database Syst Rev, 2013, 6: CD009058.
39.	Van De Voorde L, Vanneste B, Houben R,et al. Image-guided stereotactic ablative radiotherapy for the liver: a safe and effective treatment. Eur J Surg Oncol, 2015, 41(2): 249-256.
40.	Scorsetti M, Comito T, Tozzi A,et al. Final results of a phase Ⅱ trial for stereotactic body radiation therapy for patients with inoperable liver metastases from colorectal cancer. J Cancer Res Clin Oncol, 2015, 141(3): 543-553.

1. Dueland S, Hagness M, Line PD,et al. Is liver transplantation an option in colorectal cancer patients with nonresectable liver metastases and progression on all lines of standard chemotherapy? Ann Surg Oncol, 2015, 22(7): 2195-2200.
2. Hoffmann K, Bulut S, Tekbas A,et al. Is hepatic resection for non-colorectal, non-neuroendocrine liver metastases justified? Ann Surg Oncol, 2015, 22 Suppl 3: S1083-S1092.
3. Shen Y, Huang S, Hu X,et al. Clinical effect of laparoscopic hepatectomy in treating liver metastasis of colon cancer: a systematic review and meta analysis. J Clin Hepatol, 2014, 30(12): 1287-1291.
4. Ferro A, Peleteiro B, Malvezzi M,et al. Worldwide trends in gastric cancer mortality (1980-2011), with predictions to 2015, and incidence by subtype. Eur J Cancer, 2014, 50(7): 1330-1344.
5. Markar SR, Mackenzie H, Mikhail S,et al. Surgical resection of hepatic metastases from gastric cancer: outcomes from national series in England. Gastric Cancer, 2016,[Epub ahead of print].
6. Oki E, Tokunaga S, Emi Y,et al. Surgical treatment of liver metastasis of gastric cancer: a retrospective multicenter cohort study (KSCC1302). Gastric Cancer, 2016, 19(3): 968-976.
7. Elferink MA, de Jong KP, Klaase JM,et al. Metachronous metastases from colorectal cancer: a population-based study in North-East Netherlands. Int J Colorectal Dis, 2015, 30(2): 205-212.
8. Cucchetti A, Ferrero A, Cescon M,et al. Cure model survival analysis after hepatic resection for colorectal liver metastases. Ann Surg Oncol, 2015, 22(6): 1908-1914.
9. Norén A, Eriksson HG, Olsson LI. Selection for surgery and survival of synchronous colorectal liver metastases; a nationwide study. Eur J Cancer, 2016, 53: 105-114.
10. Ratti F, Schadde E, Masetti M,et al. Strategies to increase the resectability of patients with colorectal liver metastases: a multi-center case-match analysis of ALPPS and conventional two-stage hepatectomy. Ann Surg Oncol, 2015, 22(6): 1933-1942.
11. Björnsson B, Sparrelid E, Røsok B,et al. Associating liver partition and portal vein ligation for staged hepatectomy in patients with colorectal liver metastases-intermediate oncological results. Eur J Surg Oncol, 2016, 42(4): 531-537.
12. Charalampoudis P, Mantas D, Sotiropoulos GC,et al. Surgery for liver metastases from breast cancer. Future Oncol, 2015, 11(10): 1519-1530.
13. Ruiz A, Castro-Benitez C, Sebagh M,et al. Repeat hepatectomy for breast cancer liver metastases. Ann Surg Oncol, 2015, 22 Suppl 3: S1057- S1066.
14. Mehta RS, Liman AD, Passero VA,et al. Lung cancer with gastrointestinal metastasis - review of theories of metastasis with three rare case descriptions. Cancer Microenviron, 2013, 6(3): 203-211.
15. 张吉超, 邹磊, 李道堂, 等. 肺癌肝转移治疗的研究进展. 中国现代普通外科进展, 2014, 17(3): 246-248.
16. 张毅, 魏翔, 潘铁成. 非小细胞肺癌肝转移的同期外科治疗1例并文献复习. 中国肺癌杂志, 2009, 12(2): 179-182.
17. Guner A, Son T, Cho I,et al. Liver-directed treatments for liver metastasis from gastric adenocarcinoma: comparison between liver resection and radiofrequency ablation. Gastric Cancer, 2016, 19(3): 951-960.
18. Hwang JE, Kim SH, Jin J,et al. Combination of percutaneous radiofrequency ablation and systemic chemotherapy are effective treatment modalities for metachronous liver metastases from gastric cancer. Clin Exp Metastasis, 2014, 31(1): 25-32.
19. Lee CW, Kim JH, Won HJ,et al. Percutaneous radiofrequency ablation of hepatic metastases from gastric adenocarcinoma after gastrectomy. J Vasc Interv Radiol, 2015, 26(8): 1172-1179.
20. Vogl TJ, Farshid P, Naguib NN,et al. Thermal ablation therapies in patients with breast cancer liver metastases: a review. Eur Radiol, 2013, 23(3): 797-804.
21. Taşçi Y, Aksoy E, Taşkın HE,et al. A comparison of laparoscopic radiofrequency ablationversus systemic therapy alone in the treatment of breast cancer metastasis to the liver. HPB (Oxford), 2013, 15(10): 789-793.
22. Kümler I, Parner VK, Tuxen MK,et al. Clinical outcome of percutaneous RF-ablation of non-operable patients with liver metastasis from breast cancer. Radiol Med, 2015, 120(6): 536-541.
23. Vogl TJ, Gruber-Rouh T, Eichler K,et al. Repetitive transarterial chemoembolization (TACE) of liver metastases from gastric cancer: local control and survival results. Eur J Radiol, 2013, 82(2): 258-263.
24. 冯涛聚, 王炜, 李付涛. 68例胃癌肝转移瘤进展期患者介入治疗的回顾性分析. 中国实用医药, 2016, 11(10): 78-79.
25. Gruber-Rouh T, Marko C, Thalhammer A,et al. Current strategies in interventional oncology of colorectal liver metastases. Br J Radiol, 2016, 89(50): 60-69.
26. Huppert P, Wenzel T, Wietholtz H. Transcatheter arterial chemoembolization (TACE) of colorectal cancer liver metastases by irinotecan-eluting microspheres in a salvage patient population. Cardiovasc Intervent Radiol, 2014, 37(1): 154-164.
27. Fiorentini G, Aliberti C, Mulazzani L,et al. Chemoembolization in colorectal liver metastases: the rebirth. Anticancer Res, 2014, 34(2): 575-584.
28. Qiu JL, Deng MG, Li W,et al. Hepatic resection for synchronous hepatic metastasis from gastric cancer. Eur J Surg Oncol, 2013, 39(7): 694-700.
29. Ogata Y, Matono K, Tsuda H,et al. Randomized phase Ⅱ study of 5-fluorouracil hepatic arterial infusion with or without antineoplastons as an adjuvant therapy after hepatectomy for liver metastases from colorectal cancer. PLoS One, 2015, 10(3): e0120064.
30. D’Angelica MI, Correa-Gallego C, Paty PB,et al. Phase Ⅱ trial of hepatic artery infusional and systemic chemotherapy for patients with unresectable hepatic metastases from colorectal cancer: conversion to resection and long-term outcomes. Ann Surg, 2015, 261(2): 353-360.
31. Kodera Y, Fujitani K, Fukushima N,et al. Surgical resection of hepatic metastasis from gastric cancer: a review and new recommendation in the Japanese gastric cancer treatment guidelines. Gastric Cancer, 2014, 17(2): 206-212.
32. Cavanna L, Bodini FC, Stroppa EM,et al. Advanced gastric cancer with liver and lymph node metastases successfully resected after induction chemotherapy with docetaxel, cisplatin and 5-fluorouracil. Chemotherapy, 2014, 60(4): 224-227.
33. Yoshikawa T, Aoki K, Mitsuhashi Y,et al. A case of double cancer of initially unresectable sigmoid colon cancer and advanced gastric cancer treated with curative resection after mFOLFOX6 therapy. Gan To Kagaku Ryoho, 2016, 43(3): 365-368.
34. Somashekhar SP, Ashwin KR, Zaveri SS,et al. Assessment of tumor response and resection rates in unresectable colorectal liver metastases following neoadjuvant chemotherapy with cetuximab. Indian J Surg Oncol, 2016, 7(1): 11-17.
35. Li J, Xie Q, Wang W,et al. CT-guided implantation of (125)I seeds (permanent brachytherapy) for metastatic tumors of the hepatic portal system: effectiveness and safety in 13 patients. Brachytherapy, 2016, 15(2): 224-230.
36. 何津, 李强.¹²⁵I粒子植入治疗延迟性结肠癌肝转移的临床疗效. 中华肿瘤杂志, 2016, 38(3): 223-227.
37. 任庆, 熊锐华, 田秀荣, 等.¹²⁵I粒子植入联合化疗治疗结直肠癌术后肝转移的临床研究. 肿瘤防治研究, 2014, 41(6): 653-656.
38. Bala MM, Riemsma RP, Wolff R,et al. Cryotherapy for liver metastases. Cochrane Database Syst Rev, 2013, 6: CD009058.
39. Van De Voorde L, Vanneste B, Houben R,et al. Image-guided stereotactic ablative radiotherapy for the liver: a safe and effective treatment. Eur J Surg Oncol, 2015, 41(2): 249-256.
40. Scorsetti M, Comito T, Tozzi A,et al. Final results of a phase Ⅱ trial for stereotactic body radiation therapy for patients with inoperable liver metastases from colorectal cancer. J Cancer Res Clin Oncol, 2015, 141(3): 543-553.

Previous Article
Research progress of lncRNA on regulation of energy metabolism in tumor cells
Next Article
Value of serum thyroglobulin in diagnosis and monitoring of differentiated thyroid cancer

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Treatment options and prognosis of malignant tumors with hepatic metastasis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content