The research progress of magnetic resonance quantitative technique in the iron overload of the abdominal parenchyma organ_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHOU Yi ,  SONG Bin , HU Fubi , YUAN Fang

Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

SONG Bin, Email: anicesong@vip.sina.com

Keywords：

iron overload; magnetic resonance quantitative technique; abdomen

DOI：

10.7507/1007-9424.201707066

Video：

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Objective To summarize the research progress of magnetic resonance quantitative technique in the iron overload of the abdominal parenchyma organ. Methods By reviewing the related literatures domesticly and abroad, the present status and progress of abdominal magnetic resonance quantitative technique and other examinations in the study of iron overload were analyzed. Results MRI multi-sequence examination technique had changed the research model of iron overload in different organs, and had important clinical significance in imaging diagnosis of abdominal parenchyma organ damage. so far, many techniques of MRI had been used in detection of iron overload, which included signal intensity measurements(including signal intensity ratio and signal intensity difference of positive and negative phases), T2/R2 measurements, T2^*/R2^* measurements, Dixon and its derivatization, ultrashort echo time technique and susceptibility weighted imaging (including conventional susceptibility weighted imaging and quantitative magnetic sensitive imaging). Conclusion Magnetic resonance quantitative examination technique is expected to be the first choice for detection of hepatic iron overload, and can improve the early detection rate of iron overload pancreatic damage.

Citation： ZHOU Yi, SONG Bin, HU Fubi, YUAN Fang. The research progress of magnetic resonance quantitative technique in the iron overload of the abdominal parenchyma organ. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(9): 1139-1144. doi: 10.7507/1007-9424.201707066 Copy

1.	孟昭升, 贾红英, 吴学琼, 等. 铁代谢及铁过载. 医学综述, 2012, 18(1): 43-46.
2.	Wunderlich AP, Cario H, Juchems MS, et al. Noninvasive MRI-based liver iron quantification: methodic approaches, practical applicability and significance. Rofo, 2016, 188(11): 1031-1036.
3.	孙磊, 王鹏, 张亮, 等. 血色病肝脏铁沉积的病理特点分析. 中华肝脏病杂志, 2015, 6(23): 443-448.
4.	宋晓丽, 赵俊功, 程英升. MRI 评价肝脏铁过载的应用进展. 世界华人消化杂志, 2012, 20(21): 1933-1938.
5.	张子义, 刘培国, 张亮, 等. 磁感应法检测肝脏铁过载的原理分析与仿真. 中国医学物理学杂志, 2013, 32(1): 3927-3932. .
6.	金明丽, 舒健. 肝脏铁质浓度测量的研究进展. 泸州医学院学报, 2016, 39(1): 79-81.
7.	Wood JC. Use of magnetic resonance imaging to monitor iron overload. Hematol Oncol Clin North Am, 2014, 28(4): 747-764.
8.	Wood JC. Estimating tissue iron burden: current status and future prospects. Br J Haematol, 2015, 170(1): 15-28.
9.	张倩, 侯波, 王璐, 等. 磁共振成像技术在铁过载诊断及随访中的应用. 中华血液学杂志, 2015, 36(4): 302-306.
10.	曹小立, 赵明峰. 铁过载对器官功能损伤及磁共振检测铁过载研究进展. 中国实用内科杂志, 2014, 34(12): 1226-1228.
11.	olouian R, Mulla ZD, Diaz J, et al. Liver and cardiac iron deposition in patients on maintenance hemodialysis by magnetic resonance imaging T2. Iran J Kidney Dis, 2016, 10(2): 68-74.
12.	Ernst O, Sergent G, Bonvarlet P, et al. Hepatic iron overload: diagnosis and quantification with MR imaging. AJR Am J Roentgenol, 1997, 168(5): 1205-1208.
13.	Bonetti MG, Castriota-Scanderbeg A, Criconia GM, et al. Hepatic iron overload in thalassemic patients: proposal and validation of an MRI method of assessment. Pediatr Radiol, 1996, 26(9): 650-656.
14.	肖超, 顾树程, 徐燕军, 等. 磁共振成像用于血液病患者铁过载评估的初步研究. 中华血液学杂志, 2015, 36(12): 1039-1042.
15.	李春燕, 黄仲奎, 龙莉玲, 等. MRI 测量 R₂ 值与铁浓度的相关性. 实用放射学杂志, 2015, 31(11): 1872-1875.
16.	Ghugre NR, Coates TD, Nelson MD, et al. Mechanisms of tissue-iron relaxivity: nuclear magnetic resonance studies of human liver biopsy specimens. Magn Reson Med, 2005, 54(5): 1185-1193.
17.	Hernando D, Cook RJ, Diamond C, et al. Magnetic susceptibility as a B0 field strength independent MRI biomarker of liver iron overload. Magn Reson Med, 2013, 70(3): 648-656.
18.	Hernando D, Levin YS, Sirlin CB, et al. Quantification of liver iron with MRI: state of the art and remaining challenges. J Magn Reson Imaging, 2014, 40(5): 1003-1021.
19.	St Pierre TG, El-Beshlawy A, Elalfy M, et al. Multicenter validation of spin-density projection-assisted R2-MRI for the noninvasive measurement of liver iron concentration. Magn Reson Med, 2014, 71(6): 2215-2223.
20.	İdilman İS, Gümrük F, Haliloğlu M, et al. The feasibility of magnetic resonance imaging for quantification of liver, pancreas, spleen, vertebral bone marrow, and renal cortex R2^* and proton density fat fraction in transfusion-related iron overload. Turk J Haematol, 2016, 33(1): 21-27.
21.	Ibrahim EH, Khalifa AM, Eldaly AK. MRI T2^* imaging for assessment of liver iron overload: study of different data analysis approaches. Acta Radiol, 2016, 57(12): 1453-1459.
22.	Verlhac S, Morel M, Bernaudin F, et al. Liver iron overload assessment by MRI R2^* relaxometry in highly transfused pediatric patients: an agreement and reproducibility study. Diagn Interv Imaging, 2015, 96(3): 259-264.
23.	Yokoo T, Yuan Q, Sénégas J, et al. Quantitative R2^* MRI of the liver with rician noise models for evaluation of hepatic iron overload: simulation, phantom, and early clinical experience. J Magn Reson Imaging, 2015, 42(6): 1544-1559.
24.	Alústiza JM, Castiella A, De Juan MD, et al. Iron overload in the liver diagnostic and quantification. Eur J Radiol, 2007, 61(3): 499-506.
25.	金晶兰, 赵旭, 李光明, 等. 美国肝病学会血色病诊治指南要点. 临床肝胆病杂志, 2013, 29(5): 403-405.
26.	Chandarana H, Lim RP, Jensen JH, et al. Hepatic iron deposition in patients with liver disease: preliminary experience with breath-hold multiecho T2^*-weighted sequence. AJR Am J Roentgenol, 2009, 193(5): 1261-1267.
27.	范振平, 石红霞, 张文瑾, 等. 1991～2010 年国内血色病荟萃分析. 临床荟萃, 2011, 26(24): 2132-2136.
28.	Anderson LJ. Assessment of iron overload with T2^* magnetic resonance imaging. Prog Cardiovasc Dis, 2011, 54(3): 287-294.
29.	Sanches-Rocha L, Serpa B, Figueiredo E, et al. Comparison between multi-echo T2^* with and without fat saturation pulse for quantification of liver iron overload. Magn Reson Imaging, 2013, 31(10): 1704-1708.
30.	Doyle EK, Toy K, Valdez B, et al. Ultra-short echo time images quantify high liver iron. Magn Reson Med, 2017, [Epub ahead of print].
31.	Tipirneni-Sajja A, Krafft AJ, McCarville MB, et al. Radial ultrashort TE imaging removes the need for breath-holding in hepatic iron overload quantification by R2^* MRI. AJR Am J Roentgenol, 2017, 209(1): 187-194.
32.	程双娟, 肖江喜. SWI 在脑内铁过载中的应用. 国际医学放射学杂志, 2015, 38(1): 16-19, 29.
33.	Li RK, Zeng MS, Qiang JW, et al. Improving detection of iron deposition in cirrhotic liver using susceptibility-weighted imaging with emphasis on histopathological correlation. J Comput Assist Tomogr, 2017, 41(1): 18-24.
34.	Liu S, Buch S, Chen Y, et al. Susceptibility-weighted imaging: current status and future directions. NMR Biomed, 2017, 30(4): [Epub ahead of print].
35.	Sharma SD, Hernando D, Horng DE, et al. Quantitative susceptibility mapping in the abdomen as an imaging biomarker of hepatic iron overload. Magn Reson Med, 2015, 74(3): 673-683.
36.	Sharma SD, Fischer R, Schoennagel BP, et al. MRI-based quantitative susceptibility mapping (QSM) and R2^* mapping of liver iron overload: comparison with SQUID-based biomagnetic liver susceptometry. Magn Reson Med, 2017, 78(1): 264-270.

1. 孟昭升, 贾红英, 吴学琼, 等. 铁代谢及铁过载. 医学综述, 2012, 18(1): 43-46.
2. Wunderlich AP, Cario H, Juchems MS, et al. Noninvasive MRI-based liver iron quantification: methodic approaches, practical applicability and significance. Rofo, 2016, 188(11): 1031-1036.
3. 孙磊, 王鹏, 张亮, 等. 血色病肝脏铁沉积的病理特点分析. 中华肝脏病杂志, 2015, 6(23): 443-448.
4. 宋晓丽, 赵俊功, 程英升. MRI 评价肝脏铁过载的应用进展. 世界华人消化杂志, 2012, 20(21): 1933-1938.
5. 张子义, 刘培国, 张亮, 等. 磁感应法检测肝脏铁过载的原理分析与仿真. 中国医学物理学杂志, 2013, 32(1): 3927-3932. .
6. 金明丽, 舒健. 肝脏铁质浓度测量的研究进展. 泸州医学院学报, 2016, 39(1): 79-81.
7. Wood JC. Use of magnetic resonance imaging to monitor iron overload. Hematol Oncol Clin North Am, 2014, 28(4): 747-764.
8. Wood JC. Estimating tissue iron burden: current status and future prospects. Br J Haematol, 2015, 170(1): 15-28.
9. 张倩, 侯波, 王璐, 等. 磁共振成像技术在铁过载诊断及随访中的应用. 中华血液学杂志, 2015, 36(4): 302-306.
10. 曹小立, 赵明峰. 铁过载对器官功能损伤及磁共振检测铁过载研究进展. 中国实用内科杂志, 2014, 34(12): 1226-1228.
11. olouian R, Mulla ZD, Diaz J, et al. Liver and cardiac iron deposition in patients on maintenance hemodialysis by magnetic resonance imaging T2. Iran J Kidney Dis, 2016, 10(2): 68-74.
12. Ernst O, Sergent G, Bonvarlet P, et al. Hepatic iron overload: diagnosis and quantification with MR imaging. AJR Am J Roentgenol, 1997, 168(5): 1205-1208.
13. Bonetti MG, Castriota-Scanderbeg A, Criconia GM, et al. Hepatic iron overload in thalassemic patients: proposal and validation of an MRI method of assessment. Pediatr Radiol, 1996, 26(9): 650-656.
14. 肖超, 顾树程, 徐燕军, 等. 磁共振成像用于血液病患者铁过载评估的初步研究. 中华血液学杂志, 2015, 36(12): 1039-1042.
15. 李春燕, 黄仲奎, 龙莉玲, 等. MRI 测量 R₂ 值与铁浓度的相关性. 实用放射学杂志, 2015, 31(11): 1872-1875.
16. Ghugre NR, Coates TD, Nelson MD, et al. Mechanisms of tissue-iron relaxivity: nuclear magnetic resonance studies of human liver biopsy specimens. Magn Reson Med, 2005, 54(5): 1185-1193.
17. Hernando D, Cook RJ, Diamond C, et al. Magnetic susceptibility as a B0 field strength independent MRI biomarker of liver iron overload. Magn Reson Med, 2013, 70(3): 648-656.
18. Hernando D, Levin YS, Sirlin CB, et al. Quantification of liver iron with MRI: state of the art and remaining challenges. J Magn Reson Imaging, 2014, 40(5): 1003-1021.
19. St Pierre TG, El-Beshlawy A, Elalfy M, et al. Multicenter validation of spin-density projection-assisted R2-MRI for the noninvasive measurement of liver iron concentration. Magn Reson Med, 2014, 71(6): 2215-2223.
20. İdilman İS, Gümrük F, Haliloğlu M, et al. The feasibility of magnetic resonance imaging for quantification of liver, pancreas, spleen, vertebral bone marrow, and renal cortex R2^* and proton density fat fraction in transfusion-related iron overload. Turk J Haematol, 2016, 33(1): 21-27.
21. Ibrahim EH, Khalifa AM, Eldaly AK. MRI T2^* imaging for assessment of liver iron overload: study of different data analysis approaches. Acta Radiol, 2016, 57(12): 1453-1459.
22. Verlhac S, Morel M, Bernaudin F, et al. Liver iron overload assessment by MRI R2^* relaxometry in highly transfused pediatric patients: an agreement and reproducibility study. Diagn Interv Imaging, 2015, 96(3): 259-264.
23. Yokoo T, Yuan Q, Sénégas J, et al. Quantitative R2^* MRI of the liver with rician noise models for evaluation of hepatic iron overload: simulation, phantom, and early clinical experience. J Magn Reson Imaging, 2015, 42(6): 1544-1559.
24. Alústiza JM, Castiella A, De Juan MD, et al. Iron overload in the liver diagnostic and quantification. Eur J Radiol, 2007, 61(3): 499-506.
25. 金晶兰, 赵旭, 李光明, 等. 美国肝病学会血色病诊治指南要点. 临床肝胆病杂志, 2013, 29(5): 403-405.
26. Chandarana H, Lim RP, Jensen JH, et al. Hepatic iron deposition in patients with liver disease: preliminary experience with breath-hold multiecho T2^*-weighted sequence. AJR Am J Roentgenol, 2009, 193(5): 1261-1267.
27. 范振平, 石红霞, 张文瑾, 等. 1991～2010 年国内血色病荟萃分析. 临床荟萃, 2011, 26(24): 2132-2136.
28. Anderson LJ. Assessment of iron overload with T2^* magnetic resonance imaging. Prog Cardiovasc Dis, 2011, 54(3): 287-294.
29. Sanches-Rocha L, Serpa B, Figueiredo E, et al. Comparison between multi-echo T2^* with and without fat saturation pulse for quantification of liver iron overload. Magn Reson Imaging, 2013, 31(10): 1704-1708.
30. Doyle EK, Toy K, Valdez B, et al. Ultra-short echo time images quantify high liver iron. Magn Reson Med, 2017, [Epub ahead of print].
31. Tipirneni-Sajja A, Krafft AJ, McCarville MB, et al. Radial ultrashort TE imaging removes the need for breath-holding in hepatic iron overload quantification by R2^* MRI. AJR Am J Roentgenol, 2017, 209(1): 187-194.
32. 程双娟, 肖江喜. SWI 在脑内铁过载中的应用. 国际医学放射学杂志, 2015, 38(1): 16-19, 29.
33. Li RK, Zeng MS, Qiang JW, et al. Improving detection of iron deposition in cirrhotic liver using susceptibility-weighted imaging with emphasis on histopathological correlation. J Comput Assist Tomogr, 2017, 41(1): 18-24.
34. Liu S, Buch S, Chen Y, et al. Susceptibility-weighted imaging: current status and future directions. NMR Biomed, 2017, 30(4): [Epub ahead of print].
35. Sharma SD, Hernando D, Horng DE, et al. Quantitative susceptibility mapping in the abdomen as an imaging biomarker of hepatic iron overload. Magn Reson Med, 2015, 74(3): 673-683.
36. Sharma SD, Fischer R, Schoennagel BP, et al. MRI-based quantitative susceptibility mapping (QSM) and R2^* mapping of liver iron overload: comparison with SQUID-based biomagnetic liver susceptometry. Magn Reson Med, 2017, 78(1): 264-270.

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The research progress of magnetic resonance quantitative technique in the iron overload of the abdominal parenchyma organ

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