• 1. Department of Thyroid and Parathyroid Surgery Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
  • 2. Department of Wound Therapeutic Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
  • 3. Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
ZHU Jingqiang, Email: zjq-wkys@163.com
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Objective  The aim of this study is to review the molecular landscape of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Method  The relevant literatures about molecular profiling of NIFTP were retrospectively analyzed and summarized. Results  The most common mutation in NIFTP was rat sarcoma viral oncogene homolog (RAS) mutation. B-type RAF (BRAFK601E) mutation, PPARG fusion, and THADA fusion also could be seen. There was usually no BRAFV600E mutation. miRNAs also were found to be differentially expressed in NIFTP. Conclusion  The molecular profiling of NIFTP may become a new molecular marker for the diagnosis of NIFTP.

Citation: WANG Yichao, XIANG Lijuan, ZHOU Ping, ZHAO Wanjun, ZHU Jingqiang. The molecular landscape of noninvasive follicular thyroid neoplasm with papillary-like nuclear features. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(1): 110-115. doi: 10.7507/1007-9424.201807051 Copy

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