LIU Shuohui 1 , YAN Jun 1,2,4,5,6,7 , ZHANG Qiyu 1,2,4,5,6,7 , WANG Haiping 1,4,5,6,7 , LI Xun 1,3,4,5,6,7
  • 1. The First Clinical Medical College, Lanzhou University, Lanzhou 730000, P. R. China;
  • 2. The Second Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, P. R. China;
  • 3. The Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, P. R. China;
  • 4. Gansu Province Institute of Hepatopancreatobiliary, Lanzhou 730000, P. R. China;
  • 5. Gansu Province Key Laboratory of Biotherapy and Regenerative Medicine, Lanzhou 730000, P. R. China;
  • 6. Gansu Province International Science and Technology Cooperation Base of Prevention and Control of Tumors with High Incidence and Major Chronic Diseases, Lanzhou 730000, P. R. China;
  • 7. Gansu Province Liver Center of Integrated Traditional Chinese and West Medicine, Lanzhou 730000, P. R. China;
LI Xun, Email: lxdr21@126.com
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Objective To analyze factors affecting post-hepatectomy liver failure (PHLF) of patients with hepatocellular carcinoma (HCC) and explore value of combining albumin-bilirubin (ALBI) score with standardized future liver remnant (sFLR) in prediction of PHLF.Methods The clinical data of patients with HCC underwent curative hepatectomy in the Second and the Fifth Departments of General Surgery of the First Hospital of Lanzhou University from January 2016 to June 2018 were retrospectively reviewed. The risk factors of PHLF were identified through the logistic regression, the area under the receiver operating characteristic curve (AUC) was used to analyze the predictive value of the ALBI score, sFLR, or ALBI score×sFLR.Results A total of 72 patients with HCC were enrolled, all of them were the Child-Pugh A grade. The incidence of PHLF was 27.78% (20/72) in these 72 patients with HCC, which was 12.96% (7/54) and 72.22% (13/18) in the 54 patients with ALBI- Ⅰ grade and 18 patients with ALBI- Ⅱ grade respectively, the difference was statistically significant (P<0.001). The results of multivariable analysis of PHLF showed that the PLT (OR=0.030, P=0.018), ALBI grade (OR=11.758, P=0.020), and sFLR (OR=0.835, P=0.003) were identified as the independent predictors of PHLF. The AUC for the ALBI score×sFLR in predicting the PHLF was 0.892, it was greater than that of the ALBI score (AUC=0.799) or the sFLR (AUC=0.773).Conclusion Compared with Child-pugh grade, ALBI grade is more accurate in predicting PHLF of HCC patients, and combining ALBI score with sFLR is better than sFLR or ALBI score alone in predicting PHLF of patients with HCC.

Citation: LIU Shuohui, YAN Jun, ZHANG Qiyu, WANG Haiping, LI Xun. Value of combining albumin-bilirubin score with standardized future liver remnant in predicting post-hepatectomy liver failure of patient with hepatocellular carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(5): 545-550. doi: 10.7507/1007-9424.201903012 Copy

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