Research progress on association of gut microbiota and postoperative gastrointestinal dysfunction in patients after abdominal surgery_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Na ¹ , ZHOU Yong ² ,  LI Ka ¹

1. West China School of Nursing, Sichuan University / West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

LI Ka, Email: lika127@126.com

Keywords：

gut microbiota; gastrointestinal dysfunction; literature review

DOI：

10.7507/1007-9424.202104006

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To review the association of gut microbiota and postoperative gastrointestinal dysfunction (GID) in patients after abdominal surgery and to provide a new idea for the pathogenesis, prevention, and treatment of postoperative GID in patients after abdominal surgery.Method The related and latest literatures were reviewed by searching the literatures on “intestinal flora” “gut microbiota” “intestinal microbial population” “brain-gut axis” “gastrointestinal function” “gastric paralysis” “intestinal paralysis” and “ileus” from January 1, 2000 to April 2, 2021 in Chinese and English databases.Results Gut microbiota diversity was closely related to postoperative GID symptoms in patients after abdominal surgery. Gut microbiota regulated gastrointestinal motility and mucosal barrier function by metabolizing food to produce metabolites such as 5-hydroxytryptamine, melatonin, short-chain fatty acid, succinic acid, lactic acid, and so on.Conclusions The imbalance of gut microbiota is closely related to postoperative GID in patients after abdominal surgery. However, the relevant bacterial metabolites that have been found are limited at present, and the relevant mechanism needs to be further investigated.

Citation： WANG Na, ZHOU Yong, LI Ka. Research progress on association of gut microbiota and postoperative gastrointestinal dysfunction in patients after abdominal surgery. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(2): 248-254. doi: 10.7507/1007-9424.202104006 Copy

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1. Chen RY, Kung VL, Das S, et al. Duodenal microbiota in stunted undernourished children with enteropathy. N Engl J Med, 2020, 383(4): 321-333.
2. Lindenbaum J, Kent TH, Sprinz H. Malabsorption and jejunitis in American Peace Corps volunteers in Pakistan. Ann Intern Med, 1966, 65(6): 1201-1209.
3. Tognini P. Gut microbiota: a potential regulator of neurodevelopment. Front Cell Neurosci, 2017, 11: 25. doi: 10.3389/fncel.2017.00025.
4. Bhattarai Y, Williams BB, Battaglioli EJ, et al. Gut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion. Cell Host Microbe, 2018, 23(6): 775-785.
5. 傅志泉, 朱鹏翀, 李清林, 等. 大承气汤治疗胃肠功能障碍的 Meta 分析. 中华中医药学刊, 2017, 35(1): 169-172.
6. 刘海亮, 周荣斌. 肠功能障碍的发病机制认识. 中国急救医学, 2007, 27(10): 940-942.
7. 江志伟, 王刚. 延迟性术后肠麻痹的概念及防治策略. 山东大学学报(医学版), 2020, 58(5): 1-5.
8. Gero D, Gié O, Hübner M, et al. Postoperative ileus: in search of an international consensus on definition, diagnosis, and treatment. Langenbecks Arch Surg, 2017, 402(1): 149-158.
9. 刘丽蕾, 王湘英. 重症急性胰腺炎合并胃肠功能障碍的机制研究及诊治现状. 世界华人消化杂志, 2013, 21(34): 3828-3834.
10. Mazzotta E, Villalobos-Hernandez EC, Fiorda-Diaz J, et al. Postoperative ileus and postoperative gastrointestinal tract dysfunction: pathogenic mechanisms and novel treatment strategies beyond colorectal enhanced recovery after surgery protocols. Front Pharmacol, 2020, 11: 583422. doi: 10.3389/fphar.2020.583422.
11. Farmer AD, Holt CB, Downes TJ, et al. Pathophysiology, diagnosis, and management of opioid-induced constipation. Lancet Gastroenterol Hepatol, 2018, 3(3): 203-212.
12. Wiggins T. Benefits of laparoscopy in selected cases of small bowel obstruction. Lancet Gastroenterol Hepatol, 2019, 4(4): 257-259.
13. Smith K. Neurogastroenterology: ageing, ENS senescence and gastrointestinal motility. Nat Rev Gastroenterol Hepatol, 2014, 11(3): 141. doi: 10.1038/nrgastro.2014.12.
14. Brierley SM, Linden DR. Neuroplasticity and dysfunction after gastrointestinal inflammation. Nat Rev Gastroenterol Hepatol, 2014, 11(10): 611-627.
15. Loughman A, Ponsonby AL, O’Hely M, et al. Gut microbiota composition during infancy and subsequent behavioural outcomes. EBioMedicine, 2020, 52: 102640. doi: 10.1016/j.ebiom.2020.102640.
16. Ma TT, Yu SY, Li Y, et al. Randomised clinical trial: an assessment of acupuncture on specific meridian or specific acupoint vs. sham acupuncture for treating functional dyspepsia. Aliment Pharmacol Ther, 2012, 35(5): 552-561.
17. Wang Y, Zhang Y, Jiang R. Early traditional Chinese medicine bundle therapy for the prevention of sepsis acute gastrointestinal injury in elderly patients with severe sepsis. Sci Rep, 2017, 7: 46015. doi: 10.1038/srep46015.
18. Zhu MF, Xing X, Lei S, et al. Electroacupuncture at bilateral zusanli points (ST36) protects intestinal mucosal immune barrier in sepsis. Evid Based Complement Alternat Med, 2015, 2015: 639412. doi: 10.1155/2015/639412.
19. Hansen CT, Sørensen M, Møller C, et al. Effect of laxatives on gastrointestinal functional recovery in fast-track hysterectomy: a double-blind, placebo-controlled randomized study. Am J Obstet Gynecol, 2007, 196(4): 311.e1. doi: 10.1016/j.ajog.2006.10.902-7.
20. Vriesman MH, Koppen IJN, Camilleri M, et al. Management of functional constipation in children and adults. Nat Rev Gastroenterol Hepatol, 2020, 17(1): 21-39.
21. Gracie DJ, Hamlin PJ, Ford AC. The influence of the brain-gut axis in inflammatory bowel disease and possible implications for treatment. Lancet Gastroenterol Hepatol, 2019, 4(8): 632-642.
22. Black CJ, Yuan Y, Selinger CP, et al. Efficacy of soluble fibre, antispasmodic drugs, and gut-brain neuromodulators in irritable bowel syndrome: a systematic review and network meta-analysis. Lancet Gastroenterol Hepatol, 2020, 5(2): 117-131.
23. Gustafsson UO, Scott MJ, Schwenk W, et al. Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations. Clin Nutr, 2012, 31(6): 783-800.
24. Payne SC, Furness JB, Stebbing MJ. Bioelectric neuromodulation for gastrointestinal disorders: effectiveness and mechanisms. Nat Rev Gastroenterol Hepatol, 2019, 16(2): 89-105.
25. Yuan JH, Song LM, Liu Y, et al. The effects of hyperbaric oxygen therapy on pelvic radiation induced gastrointestinal complications (rectal bleeding, diarrhea, and pain): a meta-analysis. Front Oncol, 2020, 10: 390. doi: 10.3389/fonc.2020.00390.
26. Gupta N, Kumar A, Harish RK, et al. Comparison of postoperative analgesia and opioid requirement with thoracic epidural vs. continuous rectus sheath infusion in midline incision laparotomies under general anaesthesia—A prospective randomised controlled study. Indian J Anaesth, 2020, 64(9): 750-755.
27. 林璋, 祖先鹏, 谢海胜, 等. 肠道菌群与人体疾病发病机制的研究进展. 药学学报, 2016, 51(6): 843-852.
28. Moeller AH, Li Y, Mpoudi Ngole E, et al. Rapid changes in the gut microbiome during human evolution. Proc Natl Acad Sci USA, 2014, 111(46): 16431-16435.
29. Sender R, Fuchs S, Milo R. Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell, 2016, 164(3): 337-340.
30. Bäumler AJ, Sperandio V. Interactions between the microbiota and pathogenic bacteria in the gut. Nature, 2016, 535(7610): 85-93.
31. 肖锶瑶, 张纾难. 肠道菌群和呼吸系统疾病相关性的研究进展. 中国全科医学, 2021, 24(9): 1165-1172.
32. Foster JA, Rinaman L, Cryan JF. Stress & the gut-brain axis: regulation by the microbiome. Neurobiol Stress, 2017, 7: 124-136.
33. Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature, 2010, 464(7285): 59-65.
34. Goodrich JK, Waters JL, Poole AC, et al. Human genetics shape the gut microbiome. Cell, 2014, 159(4): 789-799.
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