Research progress on relation between dietary factors and risk of pancreatic cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Qingjing , LI Mao , LI Zhenlu ,  HU Weiming

Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

HU Weiming, Email: huweiming@scu.edu.cn

Keywords：

dietary factor; pancreatic cancer; prevention

DOI：

10.7507/1007-9424.202112095

Video：

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Objective To summarize the influence of dietary factors on the risk of pancreatic cancer and its possible mechanism. Method The literatures relevant to studies of the influence of dietary factors on the risk of pancreatic cancer were collected and reviewed. Results The total intakes of carbohydrate, fatty acid, protein, and vitamin affected the risk of pancreatic cancer, and the different substances belonging to the same nutrients had different effects on the risk of pancreatic cancer. In addition to nutrients, the popular beverages and different dietary patterns in recent years also affected the risk of pancreatic cancer through certain mechanisms. Conclusion Dietary factors can affect risk of pancreatic cancer through a variety of mechanisms, and it might decrease risk of pancreatic cancer by intervening in dietary factors in daily life for healthy people.

Citation： YANG Qingjing, LI Mao, LI Zhenlu, HU Weiming. Research progress on relation between dietary factors and risk of pancreatic cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(8): 1101-1108. doi: 10.7507/1007-9424.202112095 Copy

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1. Park W, Chawla A, O’Reilly EM. Pancreatic cancer: a review. JAMA, 2021, 326(9): 851-862.
2. Haller SD, Monaco ML, Essani K. The present status of immuno-oncolytic viruses in the treatment of pancreatic cancer. Viruses, 2020, 12(11): 1318. doi: 10.3390/v12111318.
3. Debras C, Chazelas E, Srour B, et al. Total and added sugar intakes, sugar types, and cancer risk: results from the prospective NutriNet-Santé cohort. Am J Clin Nutr, 2020, 112(5): 1267-1279.
4. Zhong GC, Li QJ, Yang PF, et al. Low-carbohydrate diets and the risk of pancreatic cancer: a large prospective cohort study. Carcinogenesis, 2021, 42(5): 724-732.
5. Hu CM, Tien SC, Hsieh PK, et al. High glucose triggers nucleotide imbalance through O-GlcNAcylation of key enzymes and induces KRAS mutation in pancreatic cells. Cell Metab, 2019, 29(6): 1334-1349.
6. Dooley J, Lagou V, Goveia J, et al. Heterogeneous effects of calorie content and nutritional components underlie dietary influence on pancreatic cancer susceptibility. Cell Rep, 2020, 32(2): 107880. doi: 10.1016/j.celrep.2020.107880.
7. Duan Q, Li H, Gao C, et al. High glucose promotes pancreatic cancer cells to escape from immune surveillance via AMPK-Bmi1-GATA2-MICA/B pathway. J Exp Clin Cancer Res, 2019, 38(1): 192. doi: 10.1186/s13046-019-1209-9.
8. Lauby-Secretan B, Scoccianti C, Loomis D, et al. Body fatness and cancer—Viewpoint of the IARC Working Group. N Engl J Med, 2016, 375(8): 794-798.
9. Doyle SL, Donohoe CL, Lysaght J, et al. Visceral obesity, metabolic syndrome, insulin resistance and cancer. Proc Nutr Soc, 2012, 71(1): 181-189.
10. Liu S, Manson JE, Buring JE, et al. Relation between a diet with a high glycemic load and plasma concentrations of high-sensitivity C-reactive protein in middle-aged women. Am J Clin Nutr, 2002, 75(3): 492-498.
11. Bao Y, Stolzenberg-Solomon R, Jiao L, et al. Added sugar and sugar-sweetened foods and beverages and the risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study. Am J Clin Nutr, 2008, 88(2): 431-440.
12. Navarrete-Muñoz EM, Wark PA, Romaguera D, et al. Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Clin Nutr, 2016, 104(3): 760-768.
13. Imamura F, O’Connor L, Ye Z, et al. Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction. Br J Sports Med, 2016, 50(8): 496-504.
14. Ruanpeng D, Thongprayoon C, Cheungpasitporn W, et al. Sugar and artificially sweetened beverages linked to obesity: a systematic review and meta-analysis. QJM, 2017, 110(8): 513-520.
15. Bidoli E, Pelucchi C, Zucchetto A, et al. Fiber intake and pancreatic cancer risk: a case-control study. Ann Oncol, 2012, 23(1): 264-268.
16. Hallfrisch J, Facn None, Behall KM. Mechanisms of the effects of grains on insulin and glucose responses. J Am Coll Nutr, 2000, 19(3 Suppl): 320S-325S. doi: 10.1080/07315724.2000.10718967.
17. Koulouris AI, Luben R, Banim P, et al. Dietary fiber and the risk of pancreatic cancer. Pancreas, 2019, 48(1): 121-125.
18. Naghshi S, Sadeghi O, Willett WC, et al. Dietary intake of total, animal, and plant proteins and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies. BMJ, 2020, 370: m2412. doi: 10.1136/bmj.m2412.
19. Yin J, Ren W, Huang X, et al. Protein restriction and cancer. Biochim Biophys Acta Rev Cancer, 2018, 1869(2): 256-262.
20. Huang BZ, Wang S, Bogumil D, et al. Red meat consumption, cooking mutagens, NAT1/2 genotypes and pancreatic cancer risk in two ethnically diverse prospective cohorts. Int J Cancer, 2021 Apr 12: 10.1002/ijc. 33598. doi: 10.1002/ijc.33598.
21. Petrick JL, Castro-Webb N, Gerlovin H, et al. A prospective analysis of intake of red and processed meat in relation to pancreatic cancer among African American women. Cancer Epidemiol Biomarkers Prev, 2020, 29(9): 1775-1783.
22. McCullough ML, Jacobs EJ, Shah R, et al. Meat consumption and pancreatic cancer risk among men and women in the Cancer Prevention Study-Ⅱ Nutrition Cohort. Cancer Causes Control, 2018, 29(1): 125-133.
23. Taunk P, Hecht E, Stolzenberg-Solomon R. Are meat and heme iron intake associated with pancreatic cancer? Results from the NIH-AARP diet and health cohort. Int J Cancer, 2016, 138(9): 2172-2189.
24. Molina-Montes E, Wark PA, Sánchez MJ, et al. Dietary intake of iron, heme-iron and magnesium and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort. Int J Cancer, 2012, 131(7): E1134-E1147. doi: 10.1002/ijc.27547.
25. Risch HA. Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. J Natl Cancer Inst, 2003, 95(13): 948-960.
26. Ghamarzad Shishavan N, Masoudi S, Mohamadkhani A, et al. Dietary intake of fatty acids and risk of pancreatic cancer: Golestan cohort study. Nutr J, 2021, 20(1): 69. doi: 10.1186/s12937-021-00723-3.
27. Rohrmann S, Linseisen J, Nöthlings U, et al. Meat and fish consumption and risk of pancreatic cancer: results from the European Prospective Investigation into Cancer and Nutrition. Int J Cancer, 2013, 132(3): 617-624.
28. Hidaka A, Shimazu T, Sawada N, et al. Fish, n-3 PUFA consumption, and pancreatic cancer risk in Japanese: a large, population-based, prospective cohort study. Am J Clin Nutr, 2015, 102(6): 1490-1497.
29. Genkinger JM, Wang M, Li R, et al. Dairy products and pancreatic cancer risk: a pooled analysis of 14 cohort studies. Ann Oncol, 2014, 25(6): 1106-1115.
30. Yamagiwa Y, Sawada N, Shimazu T, et al. Soy food intake and pancreatic cancer risk: the Japan Public Health Center-based Prospective Study. Cancer Epidemiol Biomarkers Prev, 2020, 29(6): 1214-1221.
31. Shen QW, Yao QY. Total fat consumption and pancreatic cancer risk: a meta-analysis of epidemiologic studies. Eur J Cancer Prev, 2015, 24(4): 278-285.
32. Cao YJ, Wang HJ, Zhang B, et al. Associations of fat and carbohydrate intake with becoming overweight and obese: an 11-year longitudinal cohort study. Br J Nutr, 2020, 124(7): 715-728.
33. Dawson DW, Hertzer K, Moro A, et al. High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model. Cancer Prev Res (Phila), 2013, 6(10): 1064-1073.
34. Jansen RJ, Robinson DP, Frank RD, et al. Fatty acids found in dairy, protein and unsaturated fatty acids are associated with risk of pancreatic cancer in a case-control study. Int J Cancer, 2014, 134(8): 1935-1946.
35. Matejcic M, Lesueur F, Biessy C, et al. Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort. Int J Cancer, 2018, 143(10): 2437-2448.
36. Ding Y, Mullapudi B, Torres C, et al. Omega-3 fatty acids prevent early pancreatic carcinogenesis via repression of the AKT pathway. Nutrients, 2018, 10(9): 1289. doi: 10.3390/nu10091289.
37. Larsson SC, Kumlin M, Ingelman-Sundberg M, et al. Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potentialmechanisms. Am J Clin Nutr, 2004, 79(6): 935-945.
38. Li D, Tang H, Wei P, et al. Vitamin C and vitamin E mitigate the risk of pancreatic ductal adenocarcinoma from meat-derived mutagen exposure in adults in a case-control study. J Nutr, 2019, 149(8): 1443-1450.
39. Maritim AC, Sanders RA, Watkins JB. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol, 2003, 17(1): 24-38.
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