Relationship between age and surgical trauma reaction and postoperative complications inpatients with colorectal cancer: a real-world data study based on DACCA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

GONG Jiaqi ^1,2 , ZENG Yu ^1,2 , LIU Ying ^1,2 , DU Yiling ^1,2 ,  WANG Xiaodong ¹ , LI Li ¹

1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. West China School of Medicine in Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

WANG Xiaodong, Email: wangxiaodong@wchscu.cn

Keywords：

colorectal cancer; age; surgical trauma reaction; postoperative complication in hospital; Database from Colorectal Cancer

DOI：

10.7507/1007-9424.202203057

Video：

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Objective To analyze the impact of age on surgical reaction and postoperative complications of patients with colorectal cancer served by West China Hospital of Sichuan University as a regional center in the Database from Colorectal Cancer (DACCA). Methods The data of DACCA was updated on January 5, 2022. All data items included age, surgical trauma reaction, elevated body temperature time, exhaust time, pain, mental status, and postoperative hospital complications. According to the age segmentation method in China, the patients can be divided into 3 groups: ≤35 years old (including infant, toddler, child, teenager and youth, set as the younger group), 36–59 years old (set as the middle-aged group), and ≥60 years old (set as the elderly group). Results After scanning, 5 224 data rows were analyzed. There was no significant difference in surgical trauma reaction (H=0.352, P=0.838), elevated body temperature time (H=3.999, P=0.135), exhaust time (H=1.940, P=0.379), mental status (H=2.075, P=0.354), incidence of postoperative complications (χ²=2.078, P=0.354), incidence of anastomotic bleeding (χ²=1.737, P=0.420), incidence of anastomotic leakage (χ²=0.573, P=0.751), and incidence of pulmonary infection (P=0.410) among different age groups, but the younger group had more severe pain (H=12.985, P=0.002) and higher incidence of inflammatory obstruction (χ²=7.789, P=0.020). Conclusions Age has little effect on trauma reaction related parameters and overall incidence of complications in colorectal cancer patients. However, younger patients with colorectal cancer showed increased pain levels and increased incidence of inflammatory obstruction after surgery. These clinical manifestations can provide clinicians with evidence for intervention, but more prospective intervention trials are needed.

Citation： GONG Jiaqi, ZENG Yu, LIU Ying, DU Yiling, WANG Xiaodong, LI Li. Relationship between age and surgical trauma reaction and postoperative complications inpatients with colorectal cancer: a real-world data study based on DACCA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(5): 666-671. doi: 10.7507/1007-9424.202203057 Copy

1.	姚宏伟, 李心翔, 崔龙, 等. 中国结直肠癌手术病例登记数据库2019年度报告: 一项全国性登记研究. 中国实用外科杂志, 2020, 40(1): 106-110, 116.
2.	汪晓东, 孟鑫宇, 刘健博, 等. 数据库研究第八部分: 结直肠癌术后风险与并发症. 中国普外基础与临床杂志, 2021, 28(3): 369-375.
3.	江龙龙, 杨鸣. 结直肠癌患者手术并发症情况和影响因素分析. 现代中西医结合杂志, 2014, 23(15): 1659-1661.
4.	鄢霆. 青年结直肠癌与老年结直肠癌的临床对比分析. 福建医科大学, 2017.
5.	Kim YW, Kim IY. Factors associated with postoperative complications and 1-year mortality after surgery for colorectal cancer in octogenarians and nonagenarians. Clin Interv Aging, 2016, 11: 689-697.
6.	Wydra J, Kruszewski W, Jasiński W, et al. Is age a risk factor of postoperative complications in colorectal cancer? Pol Przegl Chir, 2013, 85（9）: 491-495.
7.	汪晓东, 李立. 数据库建设第一部分: 个人数据的标签与结构化. 中国普外基础与临床杂志, 2019, 26(3): 335-342.
8.	汪晓东, 刘健博, 孟鑫宇, 等. 数据库建设第八部分: 结直肠癌手术反应及围术期并发症的标签与结构化. 中国普外基础与临床杂志, 2021, 28(4): 508-511.
9.	Hu M, Yu Y, Wu Z, et al. The clinical study of fast-track rehabilitation nursing in the perioperative period of therapeutic laparoscopy of colon cancer patients. J Pak Med Assoc, 2020, 70(9): 24-30.
10.	Yu S, Tang Y. Effects of comprehensive care on psychological emotions, postoperative rehabilitation and complications of colorectal cancer patients after colostomy. Am J Transl Res, 2021, 13(6): 6889-6896.
11.	Okugawa Y, Toiyama Y, Yamamoto A, et al. Lymphocyte-C-reactive protein ratio as promising new marker for predicting surgical and oncological outcomes in colorectal cancer. Ann Surg, 2020, 272(2): 342-351.
12.	郑华, 舒斌, 段光友, 等. 腹部手术后镇痛药需求量的影响因素. 临床外科杂志, 2014, 22(6): 397-400.
13.	卓恩挺, 陈雪莲, 王连臣, 等. 腹腔镜结直肠癌手术术后并发症的临床分析及预防策略. 山西医科大学学报, 2013, 44(8): 635-637.
14.	Quiroga-Centeno AC, Jerez-Torra KA, Martin-Mojica PA, et al. Risk factors for prolonged postoperative ileus in colorectal surgery: a systematic review and meta-analysis. World J Surg, 2020, 44(5): 1612-1626.
15.	廖新华, 张磊, 许延发, 等. 结、直肠癌患者术后并发症的影响因素分析. 西安交通大学学报 (医学版), 2010, 31(3): 348-350.
16.	Basdanis G, Papadopoulos VN, Michalopoulos A, et al. Colorectal cancer in patients over 70 years of age: determinants of outcome. Tech Coloproctol, 2004, 8 Suppl 1: s112-s115.
17.	康志勇. 结直肠癌术后吻合口漏的相关危险因素分析. 延边大学, 2021.
18.	康剑霞. 术后早期炎性梗阻的治疗体会 (附40例报告). 华北煤炭医学院学报, 2007, 9(5): 687-688.
19.	王勇, 张岩. 开腹手术后早期炎性肠梗阻的诊断与综合治疗. 医学与哲学, 2013, 34(8): 32-33.

1. 姚宏伟, 李心翔, 崔龙, 等. 中国结直肠癌手术病例登记数据库2019年度报告: 一项全国性登记研究. 中国实用外科杂志, 2020, 40(1): 106-110, 116.
2. 汪晓东, 孟鑫宇, 刘健博, 等. 数据库研究第八部分: 结直肠癌术后风险与并发症. 中国普外基础与临床杂志, 2021, 28(3): 369-375.
3. 江龙龙, 杨鸣. 结直肠癌患者手术并发症情况和影响因素分析. 现代中西医结合杂志, 2014, 23(15): 1659-1661.
4. 鄢霆. 青年结直肠癌与老年结直肠癌的临床对比分析. 福建医科大学, 2017.
5. Kim YW, Kim IY. Factors associated with postoperative complications and 1-year mortality after surgery for colorectal cancer in octogenarians and nonagenarians. Clin Interv Aging, 2016, 11: 689-697.
6. Wydra J, Kruszewski W, Jasiński W, et al. Is age a risk factor of postoperative complications in colorectal cancer? Pol Przegl Chir, 2013, 85（9）: 491-495.
7. 汪晓东, 李立. 数据库建设第一部分: 个人数据的标签与结构化. 中国普外基础与临床杂志, 2019, 26(3): 335-342.
8. 汪晓东, 刘健博, 孟鑫宇, 等. 数据库建设第八部分: 结直肠癌手术反应及围术期并发症的标签与结构化. 中国普外基础与临床杂志, 2021, 28(4): 508-511.
9. Hu M, Yu Y, Wu Z, et al. The clinical study of fast-track rehabilitation nursing in the perioperative period of therapeutic laparoscopy of colon cancer patients. J Pak Med Assoc, 2020, 70(9): 24-30.
10. Yu S, Tang Y. Effects of comprehensive care on psychological emotions, postoperative rehabilitation and complications of colorectal cancer patients after colostomy. Am J Transl Res, 2021, 13(6): 6889-6896.
11. Okugawa Y, Toiyama Y, Yamamoto A, et al. Lymphocyte-C-reactive protein ratio as promising new marker for predicting surgical and oncological outcomes in colorectal cancer. Ann Surg, 2020, 272(2): 342-351.
12. 郑华, 舒斌, 段光友, 等. 腹部手术后镇痛药需求量的影响因素. 临床外科杂志, 2014, 22(6): 397-400.
13. 卓恩挺, 陈雪莲, 王连臣, 等. 腹腔镜结直肠癌手术术后并发症的临床分析及预防策略. 山西医科大学学报, 2013, 44(8): 635-637.
14. Quiroga-Centeno AC, Jerez-Torra KA, Martin-Mojica PA, et al. Risk factors for prolonged postoperative ileus in colorectal surgery: a systematic review and meta-analysis. World J Surg, 2020, 44(5): 1612-1626.
15. 廖新华, 张磊, 许延发, 等. 结、直肠癌患者术后并发症的影响因素分析. 西安交通大学学报 (医学版), 2010, 31(3): 348-350.
16. Basdanis G, Papadopoulos VN, Michalopoulos A, et al. Colorectal cancer in patients over 70 years of age: determinants of outcome. Tech Coloproctol, 2004, 8 Suppl 1: s112-s115.
17. 康志勇. 结直肠癌术后吻合口漏的相关危险因素分析. 延边大学, 2021.
18. 康剑霞. 术后早期炎性梗阻的治疗体会 (附40例报告). 华北煤炭医学院学报, 2007, 9(5): 687-688.
19. 王勇, 张岩. 开腹手术后早期炎性肠梗阻的诊断与综合治疗. 医学与哲学, 2013, 34(8): 32-33.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship between age and surgical trauma reaction and postoperative complications inpatients with colorectal cancer: a real-world data study based on DACCA

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