Complex and diverse RNA modifications and cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CAO Xiaoyue ,  SHI Yujun

Institute of Clinical Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

SHI Yujun, Email: shiyujun@scu.edu.cn

Keywords：

epigenetics; RNA modification; gene expression; transcriptome

DOI：

10.7507/1007-9424.202208074

Video：

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RNA can be labeled by more than 170 chemical modifications after transcription, and these chemical modifications are collectively referred to as RNA modifications. It opened a new chapter of epigenetic research and became a major research hotspot in recent years. RNA modification regulates the expression of genes from the transcriptome level by regulating the fate of RNA, thus participating in many biological processes and disease occurrence and development. With the deepening of research, the diversity and complexity of RNA modification, as well as its physiological significance and potential as a therapeutic target, can not be ignored.

Citation： CAO Xiaoyue, SHI Yujun. Complex and diverse RNA modifications and cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(10): 1270-1272. doi: 10.7507/1007-9424.202208074 Copy

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1. Boccaletto P, Stefaniak F, Ray A, et al. MODOMICS: a database of RNA modification pathways. 2021 update. Nucleic Acids Res, 2022, 50(D1): D231-D235. doi: 10.1093/nar/gkab1083.
2. Wiener D, Schwartz S. The epitranscriptome beyond m⁶A. Nat Rev Genet, 2021, 22(2): 119-131.
3. Murakami S, Jaffrey SR. Hidden codes in mRNA: control of gene expression by m⁶A. Mol Cell, 2022, 82(12): 2236-2251.
4. Xue C, Chu Q, Zheng Q, et al. Role of main RNA modifications in cancer: N⁶-methyladenosine, 5-methylcytosine, and pseudouridine. Signal Transduct Target Ther, 2022, 7(1): 142. doi: 10.1038/s41392-022-01003-0.
5. Huang Y, Su R, Sheng Y, et al. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia. Cancer Cell, 2019, 35(4): 677-691.
6. Barbieri I, Kouzarides T. Role of RNA modifications in cancer. Nat Rev Cancer, 2020, 20(6): 303-322.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Complex and diverse RNA modifications and cancer

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