WANG Huan 1,2,3 # , LIU Yali 4 # , ZHU Min 1,2,3 , WU Kainan 1,2,3 , ZHAO Mengna 1,2,3 , HOU Haozhong 1,2,5 , WEI Chenru 1,2,5 , LI Yanyou 1,2,5 , LIAO Xuliang 1,2,5 , LI Jing 1,2,3 , JIA Yu 1,2,6 , BIAN Tianyue 1,2,3 , ZHAO Lulu 1,2,3 , MA Bin 1,2
  • 1. Evidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P.R.China;
  • 2. Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, 730000, P.R.China;
  • 3. The First Clinical Medical College of Lanzhou University, Lanzhou, 73000, P.R.China;
  • 4. Department of Neurosurgery of Second Hospital of Lanzhou University, Lanzhou, 73000, P.R.China;
  • 5. The Second Clinical Medical College of Lanzhou University, Lanzhou, 73000, P.R.China;
  • 6. The Dentistry College of Lanzhou University, Lanzhou, 73000, P.R.China;
MA Bin, Email: mab@lzu.edu.cn
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Objectives Using the ARRIVE guidelines (Animal Research Reporting: In Vivo Experiments Guidelines) to carry out a retrospective study of the reporting quality of animal studies published in Chinese journals.Methods We searched databases including CNKI, WanFang Data, VIP and CBM to July, 2018. Four reviewers independently screened literatures and extracted data. The ARRIVE guidelines were used to assess reporting quality and the comparative analysis based on different published time.Results A total of 4 342 studies were included. About the cited frequency, 73.03% studies were ≤5, and merely 29.04% studies were published in journals of CSCD. The assessment results showed that the number of reported items with "low risk" in the ARRIVE guidelines, which have 20 items, that meaning 39 sub items, more than half of sub items (51.28%, 20/39) rated as "low risk" had a compliance rate of less than 50%. Among them, 65.00% (13/20) of sub items had a lower rate of compliance with "low risk" than 10%.Conclusion The reporting quality of domestic animal studies is generally low. The coincidence rate of domestic animal studies has been improved to some extent in most of items after the ARRIVE guidelines published, however, some items of methodology, results and conclusions had problems with insufficient reporting. Therefore, we suggest that it is necessary to popularize the ARRIVE guidelines, advocate more researchers following the ARRIVE guidelines and promote endorsement of the ARRIVE Guideline by Chinese Journals to improve the design, implementation and reporting of animal experiments, and ultimately enhance the quality of animal studies.

Citation: WANG Huan, LIU Yali, ZHU Min, WU Kainan, ZHAO Mengna, HOU Haozhong, WEI Chenru, LI Yanyou, LIAO Xuliang, LI Jing, JIA Yu, BIAN Tianyue, ZHAO Lulu, MA Bin. The reporting quality of intervention animal studies published in Chinese journals: a quantitative analysis. Chinese Journal of Evidence-Based Medicine, 2019, 19(1): 89-96. doi: 10.7507/1672-2531.201808056 Copy

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