SHANG Xue 1,2,3 , WU Yanan 1,2,3 , E Fenfen 1,2,3 , LU Cuncun 4 , HOU Liangying 2,3 , GUO Kangle 1,2,3 , WANG Yan 1,2,3 , ZHOU Liying 1,2,3 , XU Meng 1,2,3 , YANG Chaoqun 1,2,3 , YANG Kehu 1,2,3 , LI Xiuxia 1,2,3
  • 1. Evidence Based Social Science Research Center/Health Technology Assessment Center, School of Public Health, Lanzhou University, Lanzhou 730000, P. R. China;
  • 2. Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou 730000, P. R. China;
  • 3. Evidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, P. R. China;
  • 4. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, P. R. China;
YANG Kehu, Email: kehuyangebm2006@126.com; LI Xiuxia, Email: lixiuxia@lzu.edu.cn
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In response to the specific requirements of nutrition research, Schwingshackl’s research group developed the NutriGrade grading system, which independently assessed the quality of evidence in randomized controlled trials and cohort studies in nutrition, aiming to summarize the associations or effects between different nutritional factors and outcomes and meet the specific needs of evidence users. It has the advantages of novel classification, quantifiability, independence and pertinence, and it has better consistency, fairness, reliability and feasibility. Well-designed prospective cohort studies are more feasible in the field of nutrition than randomized controlled trials. The grading of the evidence quality for cohort studies included the following eight items: a) risk of bias, study quality, and study limitations; b) precision; c) heterogeneity; d) directness; e) publication bias; f) funding bias; g) effect size; and h) dose-response. Based on the evaluation results of the above items, the evidence quality could be divided into four grades: high (8-10), moderate (<8), low (<6), and very low (<4). The purpose of this paper was to introduce the basic principles, specific contents, and application methods of the NutriGrade grading system for cohort studies and cite examples to provide references for relevant researchers.

Citation: SHANG Xue, WU Yanan, E Fenfen, LU Cuncun, HOU Liangying, GUO Kangle, WANG Yan, ZHOU Liying, XU Meng, YANG Chaoqun, YANG Kehu, LI Xiuxia. Interpretation of NutriGrade: a grading system to assess the quality of evidence for cohort studies on nutrition. Chinese Journal of Evidence-Based Medicine, 2022, 22(11): 1348-1357. doi: 10.7507/1672-2531.202205035 Copy

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