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find Keyword "化疗栓塞" 43 results
  • Effectiveness and Safety of TACE Combined with AHCS for Primary Hepatic Carcinomas: A Systematic Review

    Objective To evaluate the clinical effectiveness and safety of transcatheter arterial chemoembolization (TACE) combined with argon-helium cryotherapy system (AHCS) for primary hepatic carcinomas (PHC), and to provide references for clinical practice and research. Methods Such databases as The Cochrane Library, PubMed, EMbase, Web of Science, CBM, CNKI, VIP and WanFang Data were searched, and other sources like the relavant references were also retrieved to collect the randomized controlled trials (RCTs) about TACE combiend with AHCS for PHC published by May 1st, 2012. After literature screening, data extraction and quality evaluation performed by two reviewers independently according to the inclusion criteria, the meta-analysis was conducted using RevMan 5.1 software. Results A total of 16 RCTs involving 1 467 patients were included. The results of meta-analysis showed: a) The TACE+AHCS group was superior to the TACE alone group in total effective rate, complete necrosis rate, 0.5-, 1-, 1.5-, 2- and 2.5-year survival rates, AFP, CD4 and Th/Ts cells, and there were significant differences (Plt;0.05); and b) The TACE+AHCS group was superior to the AHCS alone group in 0.5-, 1.5-, 2- and 2.5-year survival rates, AFP and Th/Ts cells, and there were significant differences (Plt;0.05). Conclusion Compared with the TACE or AHCS alone, TACE combined with AHCS can improve long-term survival rate and short-term curative effect, and improve PHC patients’ immunity. However, its long-term curative effect and safety still needs to be further verified by more large sample and high quality RCTs.

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  • 艾迪注射液联合化疗治疗原发性肝细胞癌系统评价

    目的:评价艾迪注射液配合肝动脉栓塞化疗(Transcatheter arterial chemoembolization TACE)或全身化疗与照单纯TACE或单纯化疗(干预Ⅰ与干预Ⅱ)治疗原发性肝细胞癌的有效性和安全性。方法:采用Cochrane系统评价方法,计算机检索MEDLINE、CENTRAL、EMBASE、CBM、CNKI、VIP和万方数据库、Cochrane图书馆临床对照试验库等;同时互联网检索正在进行的临床试验;手工检索相关期刊和附加检索相关会议论文集。对纳入的同质研究采用RevMan50进行Meta分析。结果:Meta分析结果表明:干预Ⅰ在提高近期疗效有效率、生活质量提高率、减少骨髓抑制率、提高免疫力、提高生存率等方面优于干预Ⅱ,差异有统计学意义。但艾迪注射液联合全身化疗在提高近期疗效有效率方面无统计学意义。结论:艾迪注射液对原发性肝癌有一定的治疗作用,但由于纳入试验的方法学质量普遍较低,期待更多设计合理、严格执行的大样本随机双盲对照试验提供高质量的证据。

    Release date:2016-08-26 02:21 Export PDF Favorites Scan
  • HEPATIC ARTERIAL CHEMOEMBOLIZATION OF ADRIAMYCIN-ETHYLCELLULOSE MICROSPHERES IN THE TREATMENT OF LIVER CANCER IN RATS

    Objective To investigate the growth of tumors and the natural life length of the rats after the adriamycinethylcellulose microspheres(ADM-EC mc) were injected in the rats bearing transplantable liver cancer through their hepatic arteries.Methods ADM-EC mc were infused into the proper hepatic arteries of the Wistar rats (W256). All of the rats were divided randomly into five groups, group 1: control, group 2: normal saline, group 3: conventional ADM, group 4: placebo ethylcellulose microspheres, and group 5: ADM-EC mc. Results As compared with other four groups, the ADM-EC mc (group 5) showed the best inhibition of the growth of tumors and the longest mean life length of the rats. Conclusion Hepatic arterial infusion of ADM-EC mc can inhibit the growth of the tumor, aggravate the necrosis, and improve the effects of the chemotherapy of liver cancer.

    Release date:2016-08-28 05:30 Export PDF Favorites Scan
  • 经肝动脉化疗栓塞治疗肝癌术后并发胆管坏死4例报告

    Release date:2016-08-29 03:18 Export PDF Favorites Scan
  • TACE Combined with Thermotherapy for Primary Hepatic Carcinoma: A Meta-Analysis

    Objective To evaluate the clinical efficacy and safety of transcatheter arterial chemoembolization (TACE) combined with thermotherapy for primary hepatic carcinoma (PHC), and to provide references for clinical practice and research. Methods The following databases as The Cochrane Library, PubMed, EMbase, CBM, CNKI, VIP and WanFang Data were searched electronically, and the other sources as supplying, such as tracing related references, were also retrieved. Besides, some unknown information was also obtained by communicating with other authors. All randomized controlled trials (RCTs) on TACE combined with thermotherapy versus TACE alone were collected. The literature was screened according to inclusive criteria, data were extracted and the quality of included studies was assessed, and then meta-analysis was conducted using RevMan 5.1 software. Results A total of 17 RCTs with 907 patients were included. Meta-analysis showed that compared with TACE alone, TACE combined with thermotherapy had a significant difference in 1-year survival rate (HR=2.40, 95%CI 1.65 to 3.48, Plt;0.000 01), 2-year survival rate (HR=3.28, 95%CI 1.87 to 5.76, Plt;0.000 1), total effective rate (RR=1.59, 95%CI 1.42 to 1.79, Plt;0.000 1) and improvement rate of life quality (RR=1.79, 95%CI 1.42 to 2.25, Plt;0.000 1). The incidences of myelosuppression and alimentary canal reactions were lower in TACE combined with thermotherapy group than those in TACE alone group, but statistically significance was only found in myelosuppression (RR=0.79, 95%CI 0.69 to 0.92, P=0.001). Conclusion Compared with TACE alone, TACE combined with thermotherapy can improve long-term survival rate and short-term curative effect, ameliorate the quality of life, and tend to reduce the incidence rate of side effects. But its long-term curative effect and more comprehensive safety still needs to be further verified by more large sample and high quality RCTs.

    Release date:2016-09-07 10:59 Export PDF Favorites Scan
  • Uterine Artery Chemoembolization in the Treatment of Cesarean Scar Pregnancy

    目的 探讨子宫动脉化疗栓塞在剖宫产术后子宫切口妊娠治疗中的可行性和安全性。 方法 回顾分析2006年7月-2011年3月收治的152例剖宫产切口瘢痕妊娠行介入治疗的病例资料。 结果 152例子宫动脉化疗栓塞操作均成功。阴道大出血或不规则出血均得到有效控制。人绒毛膜促性腺激素β亚型较术前下降,差异有统计学意义(Z=−9.295,P=0.000),术后2~22 d行清宫术,术中失血3~100 mL,平均27 mL。3例行子宫切除术,子宫切除率2%。1例发生栓子脱落导致左下肢胫前动脉栓塞并发症。 结论 子宫动脉化疗栓塞治疗剖宫产术后切口妊娠可有效控制大出血、降低清宫风险、降低子宫切除风险,是治疗切口妊娠的有效可行方法之一。

    Release date:2016-09-08 09:13 Export PDF Favorites Scan
  • Treatment of Primary Hepatic Carcinoma with Three-Dimensional Conformal Radiation Therapy Combined with Transcatheter Arterial Chemoembolization

    【摘要】 目的 探讨三维适形放疗(3DCRT)联合介入栓塞化疗(TACE)治疗Ⅲ、Ⅳ期原发性肝癌的方法和临床价值。 方法 回顾性总结2006年6月-2008年12月采用3DCRT联合TACE治疗原发性肝癌的临床资料40例。 结果 3DCRT联合TACE治疗Ⅲ、Ⅳ期原发性肝癌有效率为85%。0.5、1、2年局部控制率分别为92%、70%、52%。0.5、1、2年生存率分别为75%、46%、30%,治疗不良反应轻微。 结论 3DCRT联合TACE能提高原发性肝癌患者生活质量,延长生存期,是治疗中晚期原发性肝癌的有效治疗方法之一。【Abstract】 Objective To investigate the application and clinical value of three-dimensional conformal radiation therapy (3DCRT) combined with transcatheter arterial chemoembolization (TACE) on stage Ⅲ and Ⅳ primary hepatic carcinoma. Methods A Total of 40 cases of stage Ⅲ and Ⅳ primary hepatic carcinoma treated by 3DCRT combined with TACE from June 2006 to December 2008 were analyzed retrospectively. Results The response rate was 85%. The 0.5-, 1-, and 2-year local response rates were 92%, 70%, and 52%, and the 0.5-, 1-, and 2-year survival rates were 75%, 46%, and 30%, respectively. The adverse reactions of radiotherapy were tolerable. Conclusion 3DCRT combined with TACE could improve prognosis of stage Ⅲ and Ⅳprimary hepatic carcinoma.

    Release date:2016-09-08 09:51 Export PDF Favorites Scan
  • Clinical Analysis on Bilateral Uterine Artery Chemoembolization for Caesarean Scar Pregnancy

    【摘要】 目的 探讨双侧子宫动脉化疗栓塞术治疗剖宫产子宫切口妊娠的临床应用价值。 方法 2004年3月-2009年10月确诊剖宫产子宫切口妊娠的患者25例。首先行双侧子宫动脉超选择插管,注入甲氨喋岭,再用明胶海绵条栓塞双侧子宫动脉,48~72 h内在B型超声监测下行清宫术。 结果 25例子宫动脉化疗栓塞术后复查B型超声,提示孕囊血供明显减少。22例在B型超声监测下一次性清除胚胎组织,出血量少;2例因胚胎植入肌层突向浆膜层栓塞术后加用氟尿嘧啶,未行清宫,自行排出;1例因术后切口处形成大血肿行手术治疗。 结论 双侧子宫动脉化疗栓塞术是治疗剖宫产子宫切口妊娠一种有效方法,既保留子宫,又保留其生育功能。【Abstract】 Objective To evaluate the application of bilateral uterine artery chemoembolization for caesarean scar pregnancy (CSP). Methods A total of 25 patients with CSP From March 2004 to October 2009 were selected. Bilateral uterine artery super selective catheterization was performed after injection with methotrexate, and gelatin sponge granules were injected into blateral uterine artery. Then atificial abortion was performed under B-ultrasonic scanning within 48-72 hours. Results In all 25 cases, the blood flow of the embryo decreased significantly after uterine artery chemoembolization. A total of 22 patients received artificial abortion successfully with little vaginal bleeding;two pateints received medication with 5-FU duet to the embryo near to the perimetrium, and finally the embryo expulsed spontaneously;one patient underwent hysterectomy, because a huge hematoma was formed at the incision of the uterus after uterine artery chemoembolization. Conclusion Bilateral uterine artery chemoembolization is effective for CSP, which could keep the uterus and the patients’ reproductive function.

    Release date:2016-09-08 09:51 Export PDF Favorites Scan
  • Clinical Value of Preoperative Transarterial Chemoembolization for Advanced Cervical Cancer

    【摘要】 目的 探讨中晚期宫颈癌术前动脉灌注化疗栓塞的临床价值。 方法 选择2005年6月-2009年12月35例经阴道镜活检确诊为宫颈癌临床分期Ⅱa~Ⅲb期宫颈癌患者,术前行1次子宫动脉化疗栓塞,化疗药物为博莱霉素(BLM)+顺铂(DDP)+环磷酰胺(CTX),栓塞剂为超液化碘油加明胶海绵颗粒。介入治疗后14~20 d行子宫全切加淋巴结清扫术。观察动脉灌注化疗栓塞前后肿块的大小变化、术中肿块粘连状况及出血量的多少。 结果 经介入治疗后肿块缩小32例:完全缓解(CR)3例、部分缓解(PR)29例,肿块无变化(NC)2例,进展(PD)1例,治疗有效率为91.4%。31例选择了手术治疗,手术率为88.6%。术中肿块粘连状况:无粘连24例,轻度粘连6例,中度粘连1例。术中出血量:≤100 mL 7例,100~200 mL 18例,200~400 mL 6例。 结论 中晚期宫颈癌术前动脉灌注化疗栓塞能有效地提高肿瘤切除率,降低手术风险。【Abstract】 Objective To evaluate the clinical value of preoperative transarterial chemoembolization for advanced cervical cancer. Methods A total of 35 patients with pathologically proved cervical cancer (from stage Ⅱa to Ⅲb) from June 2005 to December 2009 received preoperative transarterial chemoembolization once. Bleomycin, cisplantin and cytoxan were infused via bilateral uterine arteries, followed by arterial emboliezation with super-liquefaction iodipin and gel foam particles as embolic agent. Radical surgery was performed on the patients after 14-20 days. Volume change of mass, accretion state and haemorrhagia amount during the operation were analyzed. Results The masses deflated in 32 cases: complete response (CR) in 3, and partial response (PR) in 29. No change (NC) was seen in 3 cases. The effective rate was 91.4%. In 31 cases who underwent the operation, the operability was 88.6%, in whom non-accretionin was in 24, light accretion was in 6 and medium accretion was in 1. Haemorrhagia amount was less than 100 mL in 11 cases, 100-200 mL in 21cases, and 200-1 400 mL in 3 cases. Conclusion Preoperative chemoembolization can elevate exairesis rate and depress the operative risk effectively.

    Release date:2016-09-08 09:51 Export PDF Favorites Scan
  • Effective Analyses on Vascular Interventional Treatment of 25 Primary Liver Cancer Patients

    目的:探讨原发性肝癌经血管介入治疗的临床疗效.方法:对2006年1月至2007年6月我院诊治的25例原发性肝癌行血管介入肝动脉化疗栓塞(TACE)治疗后进行随访和回顾性分析,其中男性10例,女性15例。年龄(48±1.8)岁。所有患者术前均行AFP,CT及彩超检查。术中经股动脉穿刺插管至肝动脉造影,经肿块供血动脉注入化疗药物,用碘化油栓塞。术后3个月,6个月再次行AFP,CT及彩超检查并再次行肝动脉化疗栓塞。结果:TACE均获成功,术后经3次以上复查再行肝动脉化疗栓塞,肝脏肿块明显缩小,1例患者复查彩超,CT,AFP等均正常。结论:肝动脉化疗栓塞治疗不能手术切除的原发性肝癌是首选的治疗方法,术后应随访AFP,彩超或CT,及时发现复发,并再行介入栓塞。

    Release date:2016-09-08 10:02 Export PDF Favorites Scan
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