Clinical application of ultra-wide field fundus autofluorescence imaging_Chinese Journal of Ocular Fundus Diseases

Authors：

Xu Amin ,  Chen Changzheng

DDepartment of Ophthalmology Renmin Hospital of Wuhan University, Wuhan 430060, China;

Corresponding author：

Chen Changzheng, Email: whuchenchzh@163.com

Keywords：

Retinal diseases/diagnosis; Choroid diseases/diagnosis; Macular degeneration/diagnosis; Diagnostic techniques, ophthalmological; Fluorescence; Review

DOI：

10.3760/cma.j.issn.1005-1015.2018.01.027

Video：

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Ultra-wide field fundus autofluorescence (FAF) imaging is a new noninvasive technique with an imaging range of about 200 °. It can detect peripheral retinal lesions that cannot be found in previous FAFs and more objectively reflect intracellular content and distribution of lipofuscin in the retinal pigment epithelium (RPE) and RPE cell metabolic status. The ultra-wide field FAF can find the abnormal autofluorescence (AF) in the peripheral retina of the eyes of age-related macular degeneration (AMD), and different AF manifestations may have an impact on the diagnosis and treatment of the different AMD subtypes. It is helpful to evaluate subretinal fluid in the eyes of central serous choroidal retinopathy and can accurately detect the changes in the outer retina of the eyes without subretinal fluid. It can help to determine the type of uveitis and fully display the evolution of the disease. It can also assess the peripheral photoreceptor cell layer and RPE in patients with retinal dystrophy and retinitis pigmentosa, and comprehensively evaluate their retinal function and monitor the progress of disease. It can also assist in the evaluation of the short-term efficacy and RPE cell function after the scleral buckling surgery for patients with rhegmatogenous retinal detachment. In the future, ultra-wide field FAF may change the knowledge and intervention strategy of ocular fundus diseases and promote the clinical and scientific research in this field.

Citation： Xu Amin, Chen Changzheng. Clinical application of ultra-wide field fundus autofluorescence imaging. Chinese Journal of Ocular Fundus Diseases, 2018, 34(1): 89-92. doi: 10.3760/cma.j.issn.1005-1015.2018.01.027 Copy

1.	Dorey CK, Wu G, Ebenstein D, et al. Cell loss in the aging retina: relationship to lipofusc in accumulation and macular degeneration[J]. Invest Ophthalmol Vis Sci, 1989, 30(8): 1691-1699.
2.	Soliman AZ, Silva PS, Aiello LP, et al. Ultra-wide-field retinal imaging in detection, classification and management of diabetic retinopathy[J]. Semin Ophthalmol, 2012, 27(5): 221-227. DOI: 10.3109/08820538.2012.708812.
3.	Mrinali P, Kiss S. Ultra-wide-field fluoreseein angiography in retinal disease[J]. Curr Opin Ophthalmol, 2014, 25(3): 213-220. DOI: 10.1097/ICU.0000000000000042.
4.	Heussen FM, Tan CS, Sadda VR. Prevalence of peripheral abnormalities on ultra-widefield greenlight (532 nm) autofluorescence imaging at a tertiary care center[J]. Invest Ophthalmol Vis Sci, 2012, 53(10): 6526-6531. DOI: 10.1167/iovs.12-9909.
5.	Silva PS, Cavallerano JD, Sun JK , et al. Nonmydriatic ultrawide field retinal imaging compared with dilated standard 7-field 35-mm photography and retinal specialist examination for evaluation of diabetic retinopathy[J]. Am J Ophthalmol, 2012, 154(3): 549-559. DOI: 10.1016/j.ajo.2012.03.019.
6.	Holz FG, Bellman C, Staudt S, et al. Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration[J]. Invest Ophthalmol Vis Sci, 2001, 42(5): 1051-1056.
7.	Sepah YJ, Akhtar A, Sadiq MA, et al. Fundus autofluorescence imaging: fundamentals and clinical relevance[J]. Saudi J Ophthalmol, 2014, 28(2): 111-116. DOI: 10.1016/j.sjopt.2014.03.008.
8.	Nomura Y, Takahashi H, Tan X, et al. Widespread choroidal thickening and abnormal midperipheral fundus autofluorescence characterize exudative age-related macular degeneration with choroidal vascular hyperpermeability[J]. Clin Ophthalmol, 2015, 9: 297-304. DOI: 10.2147/OPTH.S78210.
9.	Witmer MT, Kozbial A, Daniel S, et al. Peripheral autofluorescence findings in age-related macular degeneration[J]. Acta Ophthalmol, 2012, 90(6): 428-433. DOI: 10.1111/j.1755-3768.2012.02434.x.
10.	Tan CS, Heussen F, Sadda SR. Peripheral autofluorescence and clinical findings in neovascular and non-neovascular age-related macular degeneration[J]. Ophthalmology, 2013, 120(6): 1271-1277. DOI: 10.1016/j.ophtha.2012.12.002.
11.	Writing Committee for the OPTOS PEripheral RetinA (OPERA) Study (Ancillary Study of Age-Related Eye Disease Study 2), Domalpally A, Clemons TE, et al. Peripheral retinal changes associated with age-related macular degeneration in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 report number 12 by the Age-Related Eye Disease Study 2 Optos PEripheral RetinA (OPERA) Study Research Group[J]. Ophthalmology, 2017, 124(4): 479-487. DOI: 10.1016/j.ophtha.2016.12.004.
12.	Klufas MA, Yannuzzi NA, Pang CE, et al. Feasibility and clinical utility of ultra-widefield indocyanine green angiography[J]. Retina, 2015, 35(3): 508-520. DOI: 10.1097/IAE.0000000000000318.
13.	Imamura Y, Fujiwara T, Spaide RF. Fundus autofluorescence and visual acuity in central serous chorioretinopathy[J]. Ophthalmology, 2011, 118(4): 700-705. DOI: 10.1016/j.ophtha.2010.08.017.
14.	Pang CE, Shah VP, Sarraf D, et al. Ultra-widefield imaging with autofluorescence and indocyanine green angiography in central serouschorioretinopathy[J]. Am J Ophthalmol, 2014, 158(2): 362-371. DOI: 10.1016/j.ajo.2014.04.021.
15.	Shin JY, Choi HJ, Lee J, et al. Fundus autofluorescence findings in central serous chorioretinopathy using two different confocalscanning laser ophthalmoscopes: correlation with functional and structural status[J]. Graefe’s Arch Clin Exp Ophthalmol, 2016, 254(8): 1537-1544. DOI: 10.1007/s00417-015-3244-3.
16.	Reznieek L, Seidensticker F, Stumpf C, et al. Systematic analysis of wide-field fundus autofIuorescence (FAF) imaging in posterior uveitis[J]. Curr Eye Res, 2014, 39(2): 164-171. DOI: 10.3109/02713683.2013.834938.
17.	Heussen FM, Vaseoncelos-Santos DV, Pappuru RR, et al. Ultra-wide-field green-light (532 nm) autofluorescence imaging in chronic Vogt-Koyanagi-Harada disease[J]. Ophthalmic Surg Lasers Imaging, 2011, 42(4): 272-277. DOI: 10.3928/15428877-20110505-01.
18.	Mesquida M, Llorene V, Fontenla JR, et al. Use of ultra-wide-field retinal imaging in the management of active Behçet retinal vasculitis[J]. Retina, 2014, 34(10): 2121-2127. DOI: 10.1097/IAE.0000000000000197.
19.	Hashimoto H, Kishi S. Ultra-wide-field fundus autofluorescence in multiple evanescent white dot syndrome[J]. Am J Ophthatmol, 2015, 159(4): 698-706. DOI: 10.1016/j.ajo.2015.01.015.
20.	Seidensticker F, Neubauer AS, Wasfy T, et al. Wide-field fundus autofluorescence corresponds to visual fields in ehorioretinitis patients[J]. Clin Ophthalmol, 2011, 5(11): 1667-1671. DOI: 10.2147/OPTH.S26224.
21.	Oishi A, Oishi M, Ogino K, et al. Wide-field fundus autofluorescence for retinitis pigmentosa and cone/cone-rod dystrophy[J]. Adv Exp Med Biol, 2016, 854: 307-313. DOI: 10.1007/978-3-319-17121-0_41.
22.	Ogura S, Yasukawa T, Kato A, et al. Wide-field fundus autofluorescence imaging to evaluate retinal function in patients with retinitis pigmentosa[J]. Am J Ophthalmol, 2014, 158(5): 1093-1098. DOI: 10.1016/j.ajo.2014.07.021.
23.	Oishi M, Oishi A, Ogino K, et al. Wide-field fundus autofluorescence abnormalities and visual function in patients with cone and cone-roddystrophies[J]. Invest Ophthalmol Vis Sci, 2014, 55(6): 3572-3577. DOI: 10.1167/iovs.14-13912.
24.	Oishi A, Ogino K, Makiyama Y, et al. Wide-field fundus autofluorescence imaging of retinitis pigmentosa[J]. Ophthalmology, 2013, 120(9): 1827-1834. DOI: 10.1016/j.ophtha.2013.01.050.
25.	Trichonas G, Traboulsi EI, Ehlers JP. Correlation of ultra-widefield fundus autofluorescence patterns withthe underlying genotype in retinaldystrophies and retinitis pigmentosa[J]. Ophthalmic Genet, 2017, 38(4): 320-324. DOI: 10.1080/13816810.2016.1227450.
26.	Witmer MT, Cho M, Favarone G, et al. Ultra-wide-field autofluorescence imaging in non-traumatic rhegmatogenous retinal detachment[J]. Eye, 2012, 26(9): 1209-1216. DOI: 10.1038/eye.2012.122.
27.	Salvanos P, Navaratnam J, Ma J, et al. Ultra-wide field autofluorescence imaging in the evaluation of scleral buckling surgery for retinal detachment[J]. Retina, 2013, 33(7): 1421-1427. DOI: 10.1097/IAE.0b013e318283138d.

1. Dorey CK, Wu G, Ebenstein D, et al. Cell loss in the aging retina: relationship to lipofusc in accumulation and macular degeneration[J]. Invest Ophthalmol Vis Sci, 1989, 30(8): 1691-1699.
2. Soliman AZ, Silva PS, Aiello LP, et al. Ultra-wide-field retinal imaging in detection, classification and management of diabetic retinopathy[J]. Semin Ophthalmol, 2012, 27(5): 221-227. DOI: 10.3109/08820538.2012.708812.
3. Mrinali P, Kiss S. Ultra-wide-field fluoreseein angiography in retinal disease[J]. Curr Opin Ophthalmol, 2014, 25(3): 213-220. DOI: 10.1097/ICU.0000000000000042.
4. Heussen FM, Tan CS, Sadda VR. Prevalence of peripheral abnormalities on ultra-widefield greenlight (532 nm) autofluorescence imaging at a tertiary care center[J]. Invest Ophthalmol Vis Sci, 2012, 53(10): 6526-6531. DOI: 10.1167/iovs.12-9909.
5. Silva PS, Cavallerano JD, Sun JK , et al. Nonmydriatic ultrawide field retinal imaging compared with dilated standard 7-field 35-mm photography and retinal specialist examination for evaluation of diabetic retinopathy[J]. Am J Ophthalmol, 2012, 154(3): 549-559. DOI: 10.1016/j.ajo.2012.03.019.
6. Holz FG, Bellman C, Staudt S, et al. Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration[J]. Invest Ophthalmol Vis Sci, 2001, 42(5): 1051-1056.
7. Sepah YJ, Akhtar A, Sadiq MA, et al. Fundus autofluorescence imaging: fundamentals and clinical relevance[J]. Saudi J Ophthalmol, 2014, 28(2): 111-116. DOI: 10.1016/j.sjopt.2014.03.008.
8. Nomura Y, Takahashi H, Tan X, et al. Widespread choroidal thickening and abnormal midperipheral fundus autofluorescence characterize exudative age-related macular degeneration with choroidal vascular hyperpermeability[J]. Clin Ophthalmol, 2015, 9: 297-304. DOI: 10.2147/OPTH.S78210.
9. Witmer MT, Kozbial A, Daniel S, et al. Peripheral autofluorescence findings in age-related macular degeneration[J]. Acta Ophthalmol, 2012, 90(6): 428-433. DOI: 10.1111/j.1755-3768.2012.02434.x.
10. Tan CS, Heussen F, Sadda SR. Peripheral autofluorescence and clinical findings in neovascular and non-neovascular age-related macular degeneration[J]. Ophthalmology, 2013, 120(6): 1271-1277. DOI: 10.1016/j.ophtha.2012.12.002.
11. Writing Committee for the OPTOS PEripheral RetinA (OPERA) Study (Ancillary Study of Age-Related Eye Disease Study 2), Domalpally A, Clemons TE, et al. Peripheral retinal changes associated with age-related macular degeneration in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 report number 12 by the Age-Related Eye Disease Study 2 Optos PEripheral RetinA (OPERA) Study Research Group[J]. Ophthalmology, 2017, 124(4): 479-487. DOI: 10.1016/j.ophtha.2016.12.004.
12. Klufas MA, Yannuzzi NA, Pang CE, et al. Feasibility and clinical utility of ultra-widefield indocyanine green angiography[J]. Retina, 2015, 35(3): 508-520. DOI: 10.1097/IAE.0000000000000318.
13. Imamura Y, Fujiwara T, Spaide RF. Fundus autofluorescence and visual acuity in central serous chorioretinopathy[J]. Ophthalmology, 2011, 118(4): 700-705. DOI: 10.1016/j.ophtha.2010.08.017.
14. Pang CE, Shah VP, Sarraf D, et al. Ultra-widefield imaging with autofluorescence and indocyanine green angiography in central serouschorioretinopathy[J]. Am J Ophthalmol, 2014, 158(2): 362-371. DOI: 10.1016/j.ajo.2014.04.021.
15. Shin JY, Choi HJ, Lee J, et al. Fundus autofluorescence findings in central serous chorioretinopathy using two different confocalscanning laser ophthalmoscopes: correlation with functional and structural status[J]. Graefe’s Arch Clin Exp Ophthalmol, 2016, 254(8): 1537-1544. DOI: 10.1007/s00417-015-3244-3.
16. Reznieek L, Seidensticker F, Stumpf C, et al. Systematic analysis of wide-field fundus autofIuorescence (FAF) imaging in posterior uveitis[J]. Curr Eye Res, 2014, 39(2): 164-171. DOI: 10.3109/02713683.2013.834938.
17. Heussen FM, Vaseoncelos-Santos DV, Pappuru RR, et al. Ultra-wide-field green-light (532 nm) autofluorescence imaging in chronic Vogt-Koyanagi-Harada disease[J]. Ophthalmic Surg Lasers Imaging, 2011, 42(4): 272-277. DOI: 10.3928/15428877-20110505-01.
18. Mesquida M, Llorene V, Fontenla JR, et al. Use of ultra-wide-field retinal imaging in the management of active Behçet retinal vasculitis[J]. Retina, 2014, 34(10): 2121-2127. DOI: 10.1097/IAE.0000000000000197.
19. Hashimoto H, Kishi S. Ultra-wide-field fundus autofluorescence in multiple evanescent white dot syndrome[J]. Am J Ophthatmol, 2015, 159(4): 698-706. DOI: 10.1016/j.ajo.2015.01.015.
20. Seidensticker F, Neubauer AS, Wasfy T, et al. Wide-field fundus autofluorescence corresponds to visual fields in ehorioretinitis patients[J]. Clin Ophthalmol, 2011, 5(11): 1667-1671. DOI: 10.2147/OPTH.S26224.
21. Oishi A, Oishi M, Ogino K, et al. Wide-field fundus autofluorescence for retinitis pigmentosa and cone/cone-rod dystrophy[J]. Adv Exp Med Biol, 2016, 854: 307-313. DOI: 10.1007/978-3-319-17121-0_41.
22. Ogura S, Yasukawa T, Kato A, et al. Wide-field fundus autofluorescence imaging to evaluate retinal function in patients with retinitis pigmentosa[J]. Am J Ophthalmol, 2014, 158(5): 1093-1098. DOI: 10.1016/j.ajo.2014.07.021.
23. Oishi M, Oishi A, Ogino K, et al. Wide-field fundus autofluorescence abnormalities and visual function in patients with cone and cone-roddystrophies[J]. Invest Ophthalmol Vis Sci, 2014, 55(6): 3572-3577. DOI: 10.1167/iovs.14-13912.
24. Oishi A, Ogino K, Makiyama Y, et al. Wide-field fundus autofluorescence imaging of retinitis pigmentosa[J]. Ophthalmology, 2013, 120(9): 1827-1834. DOI: 10.1016/j.ophtha.2013.01.050.
25. Trichonas G, Traboulsi EI, Ehlers JP. Correlation of ultra-widefield fundus autofluorescence patterns withthe underlying genotype in retinaldystrophies and retinitis pigmentosa[J]. Ophthalmic Genet, 2017, 38(4): 320-324. DOI: 10.1080/13816810.2016.1227450.
26. Witmer MT, Cho M, Favarone G, et al. Ultra-wide-field autofluorescence imaging in non-traumatic rhegmatogenous retinal detachment[J]. Eye, 2012, 26(9): 1209-1216. DOI: 10.1038/eye.2012.122.
27. Salvanos P, Navaratnam J, Ma J, et al. Ultra-wide field autofluorescence imaging in the evaluation of scleral buckling surgery for retinal detachment[J]. Retina, 2013, 33(7): 1421-1427. DOI: 10.1097/IAE.0b013e318283138d.

Chinese Journal of Ocular Fundus Diseases

Clinical application of ultra-wide field fundus autofluorescence imaging

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